Alam Uazman, Riley David R, Jugdey Ravinder S, Azmi Shazli, Rajbhandari Satyan, D'Août Kristiaan, Malik Rayaz A
Diabetes and Endocrinology Research, Department of Eye and Vision Sciences, Institute of Ageing and Chronic Disease, University of Liverpool and Aintree University Hospital NHS Foundation Trust, Liverpool, UK.
Division of Diabetes, Endocrinology and Gastroenterology, Institute of Human Development, University of Manchester and the Manchester Royal Infirmary, Central Manchester Hospital Foundation Trust, Manchester, UK.
Diabetes Ther. 2017 Dec;8(6):1253-1264. doi: 10.1007/s13300-017-0295-y. Epub 2017 Sep 1.
Diabetic peripheral neuropathy (DPN) is a major sequela of diabetes mellitus and may have a detrimental effect on the gait of people with this complication. DPN causes a disruption in the body's sensorimotor system and is believed to affect up to 50% of patients with diabetes mellitus, dependent on the duration of diabetes. It has a major effect on morbidity and mortality. The peripheral nervous system controls the complex series of events in gait through somatic and autonomic functions, careful balancing of eccentric and concentric muscle contractions and a reliance on the sensory information received from the plantar surface. In this literature review focussing on kinetics, kinematics and posture during gait in DPN patients, we have identified an intimate link between DPN and abnormalities in gait and demonstrated an increased risk in falls for older patients with diabetes. As such, we have identified a need for further research on the role of gait abnormalities in the development of diabetic foot ulceration and subsequent amputations.
糖尿病周围神经病变（DPN）是糖尿病的主要后遗症，可能会对患有这种并发症的人的步态产生不利影响。DPN会导致人体感觉运动系统紊乱，据信，根据糖尿病病程的不同，高达50%的糖尿病患者会受到影响。它对发病率和死亡率有重大影响。周围神经系统通过躯体和自主功能、精确平衡离心和向心肌肉收缩以及依赖从足底表面接收的感觉信息来控制步态中一系列复杂的事件。在这篇聚焦于DPN患者步态期间动力学、运动学和姿势的文献综述中，我们发现DPN与步态异常之间存在密切联系，并证明老年糖尿病患者跌倒风险增加。因此，我们发现有必要进一步研究步态异常在糖尿病足溃疡形成及随后截肢过程中的作用。
