Prashant Praveen, Pal Sat, Bansal Abhishek, Fotedar Sanjay
Department of Biochemistry, Pt. BD Sharma PGIMS Rohtak, Haryana, India.
Department of Physiology, Pt. BD Sharma PGIMS Rohtak, Haryana, India.
J Family Med Prim Care. 2024 Oct;13(10):4469-4475. doi: 10.4103/jfmpc.jfmpc_304_24. Epub 2024 Oct 18.
Diabetes mellitus (DM) poses a significant health burden globally, impacting millions due to its metabolic disruptions. Among its complications, diabetic peripheral neuropathy (DPN) is a prevalent concern, affecting sensory and motor nerves. While various diagnostic methods exist, discrepancies persist in prevalence estimates of DPN among diabetic populations.
This meta-analysis aimed to assess the prevalence of DPN in individuals with DM, focusing on sural nerve conduction velocity (NCV) measurements. Additionally, the study explored how different evaluation techniques influenced prevalence estimates.
A systematic literature search was conducted following PRISMA guidelines across multiple databases. Studies reporting sural nerve NCV measurements in diabetic patients were included. Data extraction, quality assessment, and statistical analyses were performed to synthesize findings.
Twenty-six studies met the inclusion criteria, providing insights into sural nerve NCV among diabetic individuals. Pooled analysis revealed a mean sural nerve NCV of 42.12 m/s (95% CI: 39.87-44.36), indicative of reduced conduction velocity in diabetic populations. Furthermore, sural nerve amplitude was significantly lower in diabetic individuals, with a pooled mean of 4.68 μV (95% CI: 3.11-6.25).
Individuals with type 2 DM exhibit impaired sural nerve function, as evidenced by reduced NCV and amplitude measurements. Timely NCV assessment, alongside glycemic monitoring, is crucial for identifying and managing DPN to prevent further complications. Interventions addressing glycemic control, dietary regulation, and lifestyle modifications are recommended to mitigate the progression of neuropathy in diabetic populations.
糖尿病在全球范围内构成了重大的健康负担，因其代谢紊乱影响着数百万人。在其并发症中，糖尿病周围神经病变（DPN）是一个普遍关注的问题，影响感觉神经和运动神经。虽然存在各种诊断方法，但糖尿病患者中DPN患病率的估计仍存在差异。
本荟萃分析旨在评估糖尿病患者中DPN的患病率，重点关注腓肠神经传导速度（NCV）测量。此外，该研究还探讨了不同评估技术如何影响患病率估计。
按照PRISMA指南在多个数据库中进行了系统的文献检索。纳入报告糖尿病患者腓肠神经NCV测量的研究。进行数据提取、质量评估和统计分析以综合研究结果。
26项研究符合纳入标准，为了解糖尿病个体的腓肠神经NCV提供了见解。汇总分析显示，腓肠神经平均NCV为42.12 m/s（95%CI：39.87 - 44.36），表明糖尿病患者的神经传导速度降低。此外，糖尿病个体的腓肠神经波幅明显较低，汇总平均值为4.68 μV（95%CI：3.11 - 6.25）。
2型糖尿病患者表现出腓肠神经功能受损，NCV和波幅测量值降低证明了这一点。及时进行NCV评估以及血糖监测对于识别和管理DPN以预防进一步并发症至关重要。建议采取控制血糖、饮食调节和生活方式改变等干预措施来减轻糖尿病患者神经病变的进展。
