Alonso Jose E, Han Albert Y, Kuan Edward C, Suh Jeffrey D, John Maie A St
Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
Jonsson Comprehensive Cancer Center, Ronald Reagan UCLA Medical Center, Los Angeles, California, U.S.A.
Laryngoscope. 2018 Mar;128(3):651-656. doi: 10.1002/lary.26790. Epub 2017 Sep 2.
Verrucous carcinoma (VC) is a rare, variant of squamous cell carcinoma with benign cytohistopathologic features and a generally favorable prognosis. Epidemiologic and clinical outcomes data are lacking as a result of limited cases of sinonasal VC.
To describe the incidence and determinants of survival of patients with verrucous carcinoma of the sinonasal tract between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database.
The SEER registry was utilized to calculate survival trends for patients with verrucous carcinoma of the sinonasal tract between 1973 and 2014. Patient data then was analyzed with respect to age, sex, race, and treatment modalities (surgery and radiation therapy). Overall survival (OS) and disease-specific survival (DSS) were calculated.
A total of 86 cases of VC of the sinonasal tract were identified. The cohort was comprised of 69.8% males. The mean age at diagnosis was 67.4 years. The nasal cavity was the most common primary site (51.2%), followed by the maxillary sinus (40.7%) and nasopharynx (5.8%). The median OS was 97.6 months. 89.5% of cases underwent surgery and 20.9% received both surgery and radiation therapy. Overall survival at 2, 5, and 10 years was 73%, 59%, and 36%, respectively. On multivariate analysis, advanced age (P < 0.05) and primary site (P < 0.05) were associated with worse OS and DSS, respectively. Primary nasopharyngeal tumor site was associated with reduced DSS (P < 0.05). Surgery improved OS (P < 0.001) and DSS (P < 0.001).
Verrucous carcinoma of the sinonasal tract is associated with a generally favorable prognosis. Age, primary site, and surgical therapy are independent predictors of OS and DSS, respectively. We present the first population-based analysis of sinonasal VC, thus clarifying the prognosis and reinforcing the management of this malignancy.
疣状癌（VC）是一种罕见的鳞状细胞癌变体，具有良性细胞组织病理学特征，预后通常良好。由于鼻窦VC病例有限，缺乏流行病学和临床结局数据。
使用监测、流行病学和最终结果（SEER）数据库描述1973年至2014年间鼻窦疣状癌患者的发病率和生存决定因素。
利用SEER登记处计算1973年至2014年间鼻窦疣状癌患者的生存趋势。然后分析患者数据的年龄、性别、种族和治疗方式（手术和放射治疗）。计算总生存期（OS）和疾病特异性生存期（DSS）。
共鉴定出86例鼻窦VC病例。该队列中男性占69.8%。诊断时的平均年龄为67.4岁。鼻腔是最常见的原发部位（51.2%），其次是上颌窦（40.7%）和鼻咽（5.8%）。中位OS为97.6个月。89.5%的病例接受了手术，20.9%的病例接受了手术和放射治疗。2年、5年和10年的总生存率分别为73%、59%和36%。多因素分析显示，高龄（P < 0.05）和原发部位（P < 0.05）分别与较差的OS和DSS相关。原发性鼻咽肿瘤部位与DSS降低相关（P < 0.05）。手术改善了OS（P < 0.001）和DSS（P < 0.001）。
鼻窦疣状癌的预后通常良好。年龄、原发部位和手术治疗分别是OS和DSS的独立预测因素。我们首次对鼻窦VC进行了基于人群的分析，从而明确了预后并加强了对这种恶性肿瘤的管理。
4。《喉镜》，128:651 - 656，2017年。
