聚合物胰岛细胞封装技术的进展，以限制异物反应并提供免疫隔离。
Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation.
机构信息
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, Royal College of Surgeons in Ireland and Trinity College Dublin, Dublin, Ireland.
出版信息
Curr Opin Pharmacol. 2017 Oct;36:66-71. doi: 10.1016/j.coph.2017.07.013. Epub 2017 Aug 31.
Islet transplantation for the treatment of type 1 diabetes (T1D) is hampered by the shortage of donor tissue and the need for life-long immunosuppression. The engineering of materials to limit host immune rejection opens the possibilities of utilising allogeneic and even xenogeneic cells without the need for systemic immunosuppression. Here we discuss the most recent developments in immunoisolation of transplanted cells using advanced polymeric biomaterials, utilising macroscale to nanoscale approaches, to limit aberrant immune responses.
胰岛移植治疗 1 型糖尿病（T1D）受到供体组织短缺和需要终生免疫抑制的限制。材料工程限制宿主免疫排斥反应，为利用同种甚至异种细胞提供了可能性，而无需进行全身免疫抑制。在这里，我们讨论了使用先进的聚合物生物材料进行移植细胞免疫隔离的最新进展，利用从宏观到纳米的方法来限制异常的免疫反应。
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