Stubbs R S, Griggs N J, Kelleher J P, Dickinson I K, Moat N, Rimmer D M
J Hosp Infect. 1987 May;9(3):285-90. doi: 10.1016/0195-6701(87)90126-5.
A prospective, randomized, controlled trial was conducted in 116 consecutive patients undergoing colorectal surgery to compare single dose prophylaxis with mezlocillin to cefuroxime plus metronidazole in three doses. Patients were randomized to receive either a single dose of iv mezlocillin (5.0 g) or three doses of iv cefuroxime plus metronidazole at 8-hourly intervals. The first dose was given on the operating table. The overall wound infection rate in the mezlocillin treated patients (n = 54) was 30% and in the patients treated with cefuroxime plus metronidazole (n = 56) 25%. This difference is not statistically significant. When trivial wound infections were disregarded the wound infection rates were 11% and 16% respectively, which again was not statistically significant.
对116例连续接受结直肠手术的患者进行了一项前瞻性、随机、对照试验，以比较单剂量美洛西林预防与三剂量头孢呋辛加甲硝唑预防的效果。患者被随机分为接受单剂量静脉注射美洛西林（5.0 g）或每8小时一次静脉注射三剂量头孢呋辛加甲硝唑。第一剂在手术台上给药。接受美洛西林治疗的患者（n = 54）的总体伤口感染率为30%，接受头孢呋辛加甲硝唑治疗的患者（n = 56）为25%。这种差异无统计学意义。当忽略轻微伤口感染时，伤口感染率分别为11%和16%，同样无统计学意义。
