Diamond T, Mulholland C K, Hanna W A, Parks T G
Department of Surgery, University Floor, Belfast City Hospital.
J Hosp Infect. 1988 Oct;12(3):215-9. doi: 10.1016/0195-6701(88)90009-6.
The results of a prospective randomized clinical trial to compare three dose regimens of mezlocillin with cefuroxime plus metronidazole for prophylaxis in emergency and elective colorectal surgery are reported. Severe wound infection occurred in five patients (10%) receiving mezlocillin and in four patients (7%) receiving cefuroxime and metronidazole. There were two episodes of septicaemia, each in the mezlocillin group. The total number of surgically related infections was less with cefuroxime plus metronidazole (n = 10) compared with mezlocillin (n = 17), but this was not statistically significant (P greater than 0.1).
本文报告了一项前瞻性随机临床试验的结果，该试验旨在比较美洛西林三种剂量方案与头孢呋辛加甲硝唑在急诊和择期结直肠手术中预防感染的效果。接受美洛西林治疗的5名患者（10%）和接受头孢呋辛与甲硝唑治疗的4名患者（7%）发生了严重伤口感染。美洛西林组各有2例败血症。与美洛西林组（n = 17）相比，头孢呋辛加甲硝唑组的手术相关感染总数较少（n = 10），但差异无统计学意义（P>0.1）。
