Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Semin Radiat Oncol. 2017 Oct;27(4):316-324. doi: 10.1016/j.semradonc.2017.04.001.
Normal tissue injury from irradiation is an unfortunate consequence of radiotherapy. Technologic improvements have reduced the risk of normal tissue injury; however, toxicity causing treatment breaks or long-term side effects continues to occur in a subset of patients. The molecular events that lead to normal tissue injury are complex and span a variety of biologic processes, including oxidative stress, inflammation, depletion of injured cells, senescence, and elaboration of proinflammatory and profibrogenic cytokines. This article describes selected recent advances in normal tissue radiobiology.
放疗导致的正常组织损伤是一种不幸的后果。技术的改进降低了正常组织损伤的风险;然而,在一部分患者中,仍会发生导致治疗中断或长期副作用的毒性。导致正常组织损伤的分子事件是复杂的,涉及多种生物学过程,包括氧化应激、炎症、损伤细胞耗竭、衰老和促炎及促纤维化细胞因子的产生。本文描述了正常组织放射生物学的一些最新进展。