Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Psychiatry Res. 2017 Dec;258:402-406. doi: 10.1016/j.psychres.2017.08.080. Epub 2017 Aug 30.
Oxytocin may play a role in mood regulation. Research has shown the plasma oxytocin level of patients with bipolar I disorder (BD I) during a manic episode was significantly higher than that of BD I patients of other statuses, and also that of healthy subjects. However, whether or not a difference in the level of oxytocin exists between patients with major depressive disorder (MDD) and those with BD II is unclear. This study aimed to investigate the plasma oxytocin levels in MDD and BD II patients in a depressive episode. 119 healthy controls, 135 BD II patients, and 97 MDD patients were enrolled. All of the BD II and MDD patients were drug-naïve, with baseline depressive status 17-item Hamilton Depression Rating Scale scores >15. The plasma oxytocin level of the BD II patients was significantly higher than that of the MDD patients and controls at baseline. After treatment, the plasma oxytocin level of the BD II patients increased significantly; however, in the MDD group, the oxytocin level decreased slightly after treatment. Our findings suggested more significant plasma oxytocin dysregulation in the patients in the BD II group than in the MDD patients and controls, both before and after treatment.
催产素可能在情绪调节中发挥作用。研究表明，双相 I 型障碍（BD I）患者在躁狂发作期间的血浆催产素水平明显高于其他状态的 BD I 患者，也高于健康受试者。然而，重度抑郁症（MDD）和 BD II 患者之间的催产素水平是否存在差异尚不清楚。本研究旨在探讨处于抑郁发作期的 MDD 和 BD II 患者的血浆催产素水平。共纳入 119 名健康对照者、135 名 BD II 患者和 97 名 MDD 患者。所有 BD II 和 MDD 患者均为初治，基线抑郁状态 17 项汉密尔顿抑郁评定量表评分＞15。BD II 患者的血浆催产素水平在基线时明显高于 MDD 患者和对照组。治疗后，BD II 患者的血浆催产素水平显著升高；然而，在 MDD 组中，治疗后催产素水平略有下降。我们的研究结果表明，与 MDD 患者和对照组相比，BD II 组患者在治疗前后的血浆催产素失调更为明显。
