孟加拉玫瑰红在急性和慢性肾衰竭大鼠中的药代动力学及胆汁排泄
Pharmacokinetics and biliary excretion of rose bengal in rats with acute and chronic renal failure.
作者信息
Silberstein D J, Bowmer C J, Yates M S
出版信息
J Pharm Pharmacol. 1987 May;39(5):395-8. doi: 10.1111/j.2042-7158.1987.tb03406.x.
The effects of glycerol-induced acute renal failure (ARF) and surgically induced chronic renal failure (CRF) on the pharmacokinetics and biliary excretion of rose bengal have been examined in the rat. Both the pharmacokinetics and biliary excretion of rose bengal were unaltered in either ARF or CRF. The latter results in CRF contrast with those of Tse et al (1976, Int. J. Nucl. Med. Biol. 3: 134-137) who reported decreased removal of the dye from blood and reduced biliary excretion. In addition, rose bengal behaves differently from bromosulphophthalein and indocyanine green whose hepatic uptake and initial biliary excretion are known to be decreased in ARF. The results suggest that rose bengal may have a hepato-biliary transport route which differs from that of bromosulphophthalein and indocyanine green, and the findings also emphasize the selective nature of altered organic anion uptake by the liver in ARF.
在大鼠身上研究了甘油诱导的急性肾衰竭（ARF）和手术诱导的慢性肾衰竭（CRF）对孟加拉玫瑰红药代动力学和胆汁排泄的影响。在ARF或CRF中，孟加拉玫瑰红的药代动力学和胆汁排泄均未改变。CRF的后一结果与Tse等人（1976年，《国际核医学与生物学杂志》3：134 - 137）的结果形成对比，他们报告染料从血液中的清除减少且胆汁排泄降低。此外，孟加拉玫瑰红的行为与溴磺酞钠和吲哚菁绿不同，已知后两者在ARF中的肝摄取和初始胆汁排泄会减少。结果表明，孟加拉玫瑰红可能具有与溴磺酞钠和吲哚菁绿不同的肝 - 胆转运途径，这些发现还强调了ARF中肝脏对有机阴离子摄取改变的选择性。
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