Bayer Emmanuelle M, Sparkes Imogen, Vanneste Steffen, Rosado Abel
Laboratory of Membrane Biogenesis, UMR 5200 CNRS, University of Bordeaux, 71 avenue Edouard Bourlaux, 33140 Villenave d'Ornon, France.
Biosciences, CLES, Exeter University, Geoffrey Pope Building, Stocker Rd, Exeter EX4 4QD, UK; School of Biological Sciences, University of Bristol, Bristol Life Sciences Building, 24 Tyndall Avenue, Bristol BS8 1TQ, UK.
Curr Opin Plant Biol. 2017 Dec;40:89-96. doi: 10.1016/j.pbi.2017.08.006. Epub 2017 Sep 1.
The plant endoplasmic reticulum (ER) defines the biosynthetic site of lipids and proteins destined for secretion, but also contains important signal transduction and homeostasis components that regulate multiple hormonal and developmental responses. To achieve its various functions, the ER has a unique architecture, both reticulated and highly plastic, that facilitates the spatial-temporal segregation of biochemical reactions and the establishment of inter-organelle communication networks. At the cell cortex, the cortical ER (cER) anchors to and functionally couples with the PM through largely static structures known as ER-PM contact sites (EPCS). These spatially confined microdomains are emerging as critical regulators of the geometry of the cER network, and as highly specialized signalling hubs. In this review, we share recent insights into how EPCS regulate cER remodelling, and discuss the proposed roles for plant EPCS components in the integration of environmental and developmental signals at the cER-PM interface.
植物内质网（ER）不仅是脂质和分泌型蛋白质的生物合成场所，还包含重要的信号转导和稳态成分，可调节多种激素和发育反应。为实现其各种功能，内质网具有独特的结构，呈网状且高度可塑性，这有助于生化反应的时空分隔以及细胞器间通讯网络的建立。在细胞皮层，皮层内质网（cER）通过称为内质网-质膜接触位点（EPCS）的 largely static 结构锚定在质膜（PM）上并与其功能耦合。这些空间受限的微区正逐渐成为 cER 网络几何形状的关键调节因子，以及高度特化的信号枢纽。在本综述中，我们分享了关于 EPCS 如何调节 cER 重塑的最新见解，并讨论了植物 EPCS 成分在 cER-质膜界面整合环境和发育信号中所提出的作用。
