抗菌剂的差异细胞毒性。

The differential cytotoxicity of antiseptic agents.

作者信息

Blenkharn J I

出版信息

J Pharm Pharmacol. 1987 Jun;39(6):477-9. doi: 10.1111/j.2042-7158.1987.tb03424.x.

DOI:10.1111/j.2042-7158.1987.tb03424.x

Abstract

The cytotoxicity of the antiseptic agents noxythiolin and chlorhexidine has been evaluated in-vitro using a range of tissue culture cell lines of differing degrees of neoplasticity. Noxythiolin appeared more cytotoxic than did chlorhexidine when tested against established neoplastic cell lines. By contrast, noxythiolin was not cytotoxic to normal control (non-neoplastic) cells. For chlorhexidine, the cytotoxic activity against control cells was similar to that observed for neoplastic cell lines. The results confirm an earlier observation of limited antitumour activity of noxythiolin solutions and, on the basis of differential cytotoxicity, confirm that noxythiolin is free from adverse effects against normal tissues and is safe for use as an antimicrobial agent applied to peritoneal surfaces and the healing wound.

摘要

已使用一系列不同程度肿瘤形成性的组织培养细胞系，在体外评估了防腐剂硝噻唑啉和洗必泰的细胞毒性。在针对已建立的肿瘤细胞系进行测试时，硝噻唑啉似乎比洗必泰具有更强的细胞毒性。相比之下，硝噻唑啉对正常对照（非肿瘤性）细胞没有细胞毒性。对于洗必泰，其对对照细胞的细胞毒性活性与在肿瘤细胞系中观察到的相似。这些结果证实了早期关于硝噻唑啉溶液抗肿瘤活性有限的观察结果，并且基于不同的细胞毒性，证实硝噻唑啉对正常组织没有不良影响，作为应用于腹膜表面和愈合伤口的抗菌剂使用是安全的。