Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, Colorado, USA.
J Neurol Neurosurg Psychiatry. 2018 Jan;89(1):95-104. doi: 10.1136/jnnp-2017-316115. Epub 2017 Sep 2.
Sleep is a fundamental homeostatic process, and disorders of sleep can greatly affect quality of life. Parkinson's disease (PD) is highly comorbid for a spectrum of sleep disorders and deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been reported to improve sleep architecture in PD. We studied local field potential (LFP) recordings in PD subjects undergoing STN-DBS over the course of a full-night's sleep. We examined the changes in oscillatory activity recorded from STN between ultradian sleep states to determine whether sleep-stage dependent spectral patterns might reflect underlying dysfunction. For this study, PD (n=10) subjects were assessed with concurrent polysomnography and LFP recordings from the DBS electrodes, for an average of 7.5 hours in 'off' dopaminergic medication state. Across subjects, we found conserved spectral patterns among the canonical frequency bands (delta 0-3 Hz, theta 3-7 Hz, alpha 7-13 Hz, beta 13-30 Hz, gamma 30-90 Hz and high frequency 90-350 Hz) that were associated with specific sleep cycles: delta (0-3 Hz) activity during non-rapid eye movement (NREM) associated stages was greater than during Awake, whereas beta (13-30 Hz) activity during NREM states was lower than Awake and rapid eye movement (REM). In addition, all frequency bands were significantly different between NREM states and REM. However, each individual subject exhibited a unique mosaic of spectral interrelationships between frequency bands. Our work suggests that LFP recordings from human STN differentiate between sleep cycle states, and sleep-state specific spectral mosaics may provide insight into mechanisms underlying sleep pathophysiology.
睡眠是一种基本的稳态过程，睡眠障碍会极大地影响生活质量。帕金森病（PD）与一系列睡眠障碍高度并存，并且已经报道深部脑刺激（DBS）丘脑底核（STN）可改善 PD 的睡眠结构。我们在 PD 患者接受 STN-DBS 的整个夜间睡眠过程中研究了局部场电位（LFP）记录。我们检查了 STN 中记录的振荡活动在超慢波睡眠状态之间的变化，以确定睡眠阶段依赖的光谱模式是否可能反映潜在的功能障碍。在这项研究中，PD（n=10）患者在停用多巴胺能药物状态下同时进行多导睡眠图和 DBS 电极的 LFP 记录，平均记录时间为 7.5 小时。在所有受试者中，我们发现经典频带（0-3 Hz 的 delta 波、3-7 Hz 的 theta 波、7-13 Hz 的 alpha 波、13-30 Hz 的 beta 波、30-90 Hz 的 gamma 波和 90-350 Hz 的高频波）之间存在保守的光谱模式，这些模式与特定的睡眠周期相关：非快速眼动（NREM）相关阶段的 delta（0-3 Hz）活动大于觉醒时，而 NREM 状态下的 beta（13-30 Hz）活动低于觉醒和快速眼动（REM）时。此外，所有频带在 NREM 状态和 REM 之间均有显著差异。然而，每个个体患者在频带之间的光谱相互关系上都表现出独特的镶嵌模式。我们的工作表明，来自人类 STN 的 LFP 记录可区分睡眠周期状态，并且睡眠状态特异性的光谱镶嵌可能为睡眠病理生理学的机制提供深入了解。
