Kolb Rachel, Abosch Aviva, Felsen Gidon, Thompson John A
Department of Bioengineering, University of Colorado School of Medicine, Aurora, Colorado, USA.
Department of Neurosurgery, University of Colorado School of Medicine, Aurora, Colorado, USA.
Physiol Rep. 2017 Jun;5(12). doi: 10.14814/phy2.13322.
Identification of brain structures traversed during implantation of deep brain-stimulating (DBS) electrodes into the subthalamic nucleus (STN-DBS) for the treatment of Parkinson's disease (PD) frequently relies on subjective correspondence between kinesthetic response and multiunit activity. However, recent work suggests that local field potentials (LFP) could be used as a more robust signal to objectively differentiate subcortical structures. The goal of this study was to analyze the spectral properties of LFP collected during STN-DBS in order to objectively identify commonly traversed brain regions and improve our understanding of aberrant oscillations in the PD-related pathophysiological cortico-basal ganglia network. In 21 PD patients, LFP were collected and analyzed during STN-DBS implantation surgery. Spectral power for delta-, theta-, alpha-, low-beta-, and high-beta-frequency bands was assessed at multiple depths throughout the subcortical structures traversed on the trajectory to the ventral border of STN. Similar to previous findings, beta-band oscillations had an increased magnitude within the borders of the motor-related area of STN, however, across several subjects, we also observed increased high-beta magnitude within the borders of thalamus. Comparing across all patients using relative power, we observed a gradual increase in the magnitude of both low- and high-beta-frequency bands as the electrode descended from striatum to STN. These results were also compared with frequency bands below beta, and similar trends were observed. Our results suggest that LFP signals recorded during the implantation of a DBS electrode evince distinct oscillatory signatures that distinguish subcortical structures.
在将深部脑刺激（DBS）电极植入丘脑底核（STN-DBS）以治疗帕金森病（PD）的过程中，确定所穿过的脑结构通常依赖于动觉反应与多单位活动之间的主观对应关系。然而，最近的研究表明，局部场电位（LFP）可作为一种更可靠的信号，用于客观地区分皮层下结构。本研究的目的是分析在STN-DBS过程中收集的LFP的频谱特性，以便客观地识别常见的穿过脑区，并增进我们对帕金森病相关病理生理皮质-基底神经节网络中异常振荡的理解。在21例帕金森病患者中，在STN-DBS植入手术期间收集并分析了LFP。在通向STN腹侧边界的轨迹上所穿过的整个皮层下结构的多个深度处，评估了δ、θ、α、低β和高β频段的频谱功率。与先前的研究结果相似，β频段振荡在STN的运动相关区域边界内幅度增加，然而，在多个受试者中，我们还观察到丘脑边界内高β幅度增加。使用相对功率对所有患者进行比较，我们观察到随着电极从纹状体下降到STN，低β和高β频段的幅度逐渐增加。这些结果还与低于β的频段进行了比较，并观察到了类似的趋势。我们的结果表明，在DBS电极植入过程中记录的LFP信号显示出区分皮层下结构的独特振荡特征。
