Parikh Rohan C, McLaurin Kimmie K, Margulis Andrea V, Mauskopf Josephine, Ambrose Christopher S, Pavilack Melissa, Candrilli Sean D
RTI Health Solutions, Research Triangle Park, NC, USA.
AstraZeneca, Gaithersburg, MD, USA.
Infect Dis Ther. 2017 Dec;6(4):477-486. doi: 10.1007/s40121-017-0167-9. Epub 2017 Sep 2.
Respiratory syncytial virus (RSV) is the leading cause of hospitalization among infants in the United States, and the risk for RSV hospitalizations is greater for infants born preterm. Recent studies in preterm and term infants have shown that RSV hospitalization rates vary considerably depending on infant chronologic age. This study sought to aggregate the data available from published literature and from nationally representative databases of US infant hospitalizations to generate a composite description of the effect of young chronologic age on RSV hospitalizations among US preterm and term infants by individual month of age.
Data describing the relative incidence of RSV hospitalizations by individual month of chronologic age during the first year of life were obtained from recently published studies, the 2006-2011 National Inpatient Sample databases, and the 2006 and 2009 Kids Inpatient Databases.
All data sources showed that ≥20% of infant RSV hospitalizations occurred in the second month of life and >50% and >75% of RSV hospitalizations were observed during the first 3 and 6 months of life, respectively. These findings were consistent for both preterm and term infants.
Data from multiple sources demonstrate that the greatest risk of RSV hospitalization occurs during the first 6 months of life among US preterm and term infants. Strategies to prevent infant RSV hospitalizations should be targeted to infants during the first months of life.
AstraZeneca.
呼吸道合胞病毒（RSV）是美国婴儿住院的主要原因，早产婴儿患RSV住院的风险更高。最近对早产和足月婴儿的研究表明，RSV住院率因婴儿的实际年龄而有很大差异。本研究旨在汇总已发表文献和美国婴儿住院情况的全国代表性数据库中的可用数据，以逐月描述实际年龄对美国早产和足月婴儿RSV住院的影响。
从最近发表的研究、2006 - 2011年全国住院患者样本数据库以及2006年和2009年儿童住院患者数据库中获取描述生命第一年中按实际年龄逐月划分的RSV住院相对发病率的数据。
所有数据源均显示，≥20%的婴儿RSV住院发生在出生后第二个月，分别有>50%和>75%的RSV住院发生在出生后的前3个月和6个月。早产和足月婴儿的这些结果一致。
来自多个来源的数据表明，美国早产和足月婴儿在出生后前6个月发生RSV住院的风险最高。预防婴儿RSV住院的策略应针对出生后头几个月的婴儿。
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