Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung & Chang Gung University, College of Medicine, Keelung 204, Taiwan.
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou & Chang Gung University, Taoyuan 333, Taiwan.
Nutrients. 2020 Mar 20;12(3):836. doi: 10.3390/nu12030836.
Study on the impact of pretreatment malnutrition on treatment outcomes in locally advanced head and neck cancer (LAHNC) patients is still lacking. We prospectively collected various malnutrition assessment methods including nutrition indexes, inflammatory biomarkers, and lean body mass index (LBMI) data before treatments. The one year mortality rate was assessed, and the factors associated with this outcome were investigated. Furthermore, the association between malnutrition assessment methods was examined. A total of 113 patients were enrolled. By prognostic stratification based on the prognostic nutritional index (PNI) and platelet-to-lymphocyte ratio (PLR) combination, the low PNI/high PLR group had highest and the high PNI/low PLR group had the lowest mortality rate. Furthermore, the PNI was positively correlated with the LBMI, and the PLR was inversely correlated with the LBMI. PNI and PLR were found to be independent prognostic factors of one year mortality and also associated with the loss of muscle.
关于治疗局部晚期头颈部癌症（LAHNC）患者前营养不良对治疗结果影响的研究仍然缺乏。我们前瞻性地收集了各种营养不良评估方法，包括治疗前的营养指标、炎症生物标志物和瘦体重指数（LBMI）数据。评估了一年的死亡率，并研究了与该结果相关的因素。此外，还研究了营养不良评估方法之间的相关性。共纳入 113 例患者。根据预后营养指数（PNI）和血小板与淋巴细胞比值（PLR）组合的预后分层，低 PNI/高 PLR 组的死亡率最高，高 PNI/低 PLR 组的死亡率最低。此外，PNI 与 LBMI 呈正相关，PLR 与 LBMI 呈负相关。PNI 和 PLR 是一年死亡率的独立预后因素，并且与肌肉丧失有关。
