改良婴幼儿孤独症检查表（M-CHAT）在社区诊所诊断孤独症和其他发育障碍的准确性。
Accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in Detecting Autism and Other Developmental Disorders in Community Clinics.
机构信息
Lau King Howe Memorial Children Clinic, Divisional Health Office & Department of Pediatrics, Sibu Hospital, KM 8, Old Oya Road, 96000, Sibu, Sarawak, Malaysia.
Clinical Research Center, Sibu Hospital, Sibu, Sarawak, Malaysia.
出版信息
J Autism Dev Disord. 2018 Jan;48(1):28-35. doi: 10.1007/s10803-017-3287-x.
This study determined the accuracy of Modified Checklist for Autism in Toddlers (M-CHAT) in detecting toddlers with autism spectrum disorder (ASD) and other developmental disorders (DD) in community mother and child health clinics. We analysed 19,297 eligible toddlers (15-36 months) who had M-CHAT performed in 2006-2011. Overall sensitivities for detecting ASD and all DD were poor but better in the 21 to <27 months and 27-36-month age cohorts (54.5-64.3%). Although positive predictive value (PPV) was poor for ASD, especially the younger cohort, positive M-CHAT helped in detecting all DD (PPV = 81.6%). This suggested M-CHAT for screening ASD was accurate for older cohorts (>21 months) and a useful screening tool for all DD.
本研究旨在确定改良婴幼儿孤独症检查表（M-CHAT）在社区母婴健康诊所中检测孤独症谱系障碍（ASD）和其他发育障碍（DD）患儿的准确性。我们分析了 2006 年至 2011 年间在社区母婴健康诊所中进行的 19297 名符合条件的 15-36 月龄幼儿。总体而言，检测 ASD 和所有 DD 的敏感性均较差，但在 21-<27 月龄和 27-36 月龄年龄组中较好（54.5-64.3%）。尽管 ASD 的阳性预测值（PPV）较差，尤其是在年龄较小的队列中，但阳性 M-CHAT 有助于检测所有 DD（PPV=81.6%）。这表明 M-CHAT 用于筛查 ASD 在较大年龄组（>21 个月）中具有准确性，并且是一种用于所有 DD 的有用筛查工具。
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