Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, South Australia, Australia.
Centre for Heart Rhythm Disorders, South Australian Health and Medical Research Institute, University of Adelaide and Royal Adelaide Hospital, South Australia, Australia.
Int J Cardiol. 2017 Nov 1;246:46-52. doi: 10.1016/j.ijcard.2017.05.133.
Whilst high levels of alcohol consumption are known to be associated with atrial fibrillation (AF), it is unclear if any level of alcohol consumption can be recommended to prevent the onset of the condition. The aim of this review is to characterise the association between chronic alcohol intake and incident AF.
Electronic literature searches were undertaken using PubMed and Embase databases up to 1 February 2016 to identify studies examining the impact of alcohol on the risk of incident AF. Prospective studies reporting on at least three levels of alcohol intake and published in English were eligible for inclusion. Studies of a retrospective or case control design were excluded. The primary study outcome was development of incident AF. Consistent with previous studies, high levels of alcohol intake were associated with an increased incident AF risk (HR 1.34, 95% CI 1.20-1.49, p<0.001). Moderate levels of alcohol intake were associated with a heightened AF risk in males (HR 1.26, 95% CI 1.04-1.54, p=0.02) but not females (HR 1.03, 95% CI 0.86-1.25, p=0.74). Low alcohol intake, of up to 1 standard drink (SD) per day, was not associated with AF development (HR 0.95, 95% CI 0.85-1.06, p=0.37).
Low levels of alcohol intake are not associated with the development of AF. Gender differences exist in the association between moderate alcohol intake and AF with males demonstrating greater increases in risk, whilst high alcohol intake is associated with a heightened AF risk across both genders.
虽然已知大量饮酒与心房颤动（AF）有关，但尚不清楚任何水平的饮酒量都可以预防这种疾病的发生。本研究的目的是描述慢性酒精摄入与房颤发病之间的关系。
使用 PubMed 和 Embase 数据库进行电子文献检索，检索时间截至 2016 年 2 月 1 日，以确定研究酒精对房颤发病风险影响的研究。符合条件的研究包括至少报告 3 个饮酒水平和用英语发表的前瞻性研究。排除回顾性或病例对照设计的研究。主要研究结果为新发房颤。与以往研究一致，大量饮酒与新发房颤风险增加相关（HR 1.34，95%CI 1.20-1.49，p<0.001）。中度饮酒与男性房颤风险增加相关（HR 1.26，95%CI 1.04-1.54，p=0.02），但与女性无关（HR 1.03，95%CI 0.86-1.25，p=0.74）。每天不超过 1 标准杯的低酒精摄入量与房颤发病无关（HR 0.95，95%CI 0.85-1.06，p=0.37）。
低水平饮酒与房颤的发生无关。中度饮酒与房颤之间的关联存在性别差异，男性风险增加更为显著，而大量饮酒与两性房颤风险增加有关。
