Hospital Central Dr. Urquinaona, Maracaibo, Venezuela.
Universidad del Zulia, Maracaibo, Venezuela.
Med Clin (Barc). 2018 May 11;150(9):336-340. doi: 10.1016/j.medcli.2017.06.064. Epub 2017 Sep 1.
To compare plasma N-terminal pro-atrial natriuretic peptide concentrations in preeclamptic patients and healthy normotensive pregnant women.
A cases-controls study was done with 180 patients at Hospital Central Dr. Urquinaona, Maracaibo, Venezuela, that included 90 preeclamptic patients (group A; cases) and 90 healthy normotensive pregnant women selected with the same age and body mass index similar to group A (group B; controls). Blood samples were collected one hour after admission and prior to administration of any medication in group A to determine plasma N-terminal pro-atrial natriuretic peptide and other laboratory parameters.
Plasma N-terminal pro-atrial natriuretic peptide concentrations in group A (mean 1.01 [0.26] pg/mL) showed a significant difference when compared with patients in group B (mean 0.55 [0.07] pg/mL; P<.001]. There was no significant correlation with systolic and diastolic blood pressure values in preeclamptic patients (P=ns). A cut-off value of 0.66ng/mL had an area under the curve of 0.93, sensitivity of 87.8%, specificity of 83.3%, a positive predictive value of 84.0% and a negative predictive value of 87.2%, with a diagnostic accuracy of 85.6%.
Preeclamptic patients have significantly higher concentrations of plasma N-terminal pro-atrial natriuretic peptide compared with healthy normotensive pregnant women, with high predictive values for diagnosis.
比较先兆子痫患者与健康血压正常孕妇的血浆 N 末端脑钠肽前体浓度。
委内瑞拉马拉开波市中央乌尔基纳翁纳医院进行了一项病例对照研究，共纳入 180 例患者，包括 90 例先兆子痫患者（A 组；病例）和 90 例健康血压正常孕妇（B 组；对照组），年龄和体重指数与 A 组相似。A 组患者入院后 1 小时采集血样，在给予任何药物前测定血浆 N 末端脑钠肽前体和其他实验室参数。
A 组（平均 1.01[0.26]pg/mL）的血浆 N 末端脑钠肽前体浓度与 B 组（平均 0.55[0.07]pg/mL；P<.001）相比有显著差异。与先兆子痫患者的收缩压和舒张压值无显著相关性（P=ns）。0.66ng/mL 截断值的曲线下面积为 0.93，敏感性为 87.8%，特异性为 83.3%，阳性预测值为 84.0%，阴性预测值为 87.2%，诊断准确率为 85.6%。
与健康血压正常孕妇相比，先兆子痫患者的血浆 N 末端脑钠肽前体浓度显著升高，对诊断具有较高的预测价值。
