Senöz S, Sahin N, Ozcan T, Direm B, Gökmen O
Dr. Zekai Tahir Burak Women's Hospital, Ankara, Turkey.
Eur J Obstet Gynecol Reprod Biol. 1995 Oct;62(2):173-7. doi: 10.1016/0301-2115(95)02191-9.
Atrial natriuretic peptide (ANP) is a family of peptides secreted by the heart, affecting the cardiovascular, renal and endocrine systems. This study questions previous research findings regarding elevated ANP levels, despite vasoconstriction and hypovolemia, in preeclamptic patients.
Seventeen patients with preeclampsia, 5 with superimposed preeclampsia with chronic hypertension and 17 normotensive pregnant women were compared with respect to plasma ANP levels. Seventeen non-pregnant women were taken as the control group. All the women, except the ones with superimposed preeclampsia, were age matched and in their third trimester.
ANP levels in the non-pregnant women (6.9 +/- 0.7 pg/ml) were not different from those in the normotensive pregnant women (6.4 +/- 0.7 pg/ml). ANP levels were significantly higher in women with preeclampsia (10.8 +/- 1.8 pg/ml) or superimposed preeclampsia (9.7 +/- 1.4 pg/ml) than in normotensive pregnant women and normal non-pregnant women (P < 0.05). According to the literature, there is a volume depletion in preeclamptic women. However, this wasn't demonstrated in our study group.
ANP levels in preeclamptic women were found to be higher than those in normotensive pregnant women. The etiology still remains obscure.
心房利钠肽（ANP）是心脏分泌的一类肽，影响心血管、肾脏和内分泌系统。本研究对先前关于子痫前期患者尽管存在血管收缩和血容量不足但ANP水平升高的研究结果提出质疑。
比较了17名单纯子痫前期患者、5名合并慢性高血压的子痫前期患者以及17名血压正常的孕妇的血浆ANP水平。选取17名非孕女性作为对照组。除合并慢性高血压的子痫前期患者外，所有女性年龄匹配且均处于孕晚期。
非孕女性的ANP水平（6.9±0.7 pg/ml）与血压正常的孕妇（6.4±0.7 pg/ml）无差异。子痫前期患者（10.8±1.8 pg/ml）或合并慢性高血压的子痫前期患者（9.7±1.4 pg/ml）的ANP水平显著高于血压正常的孕妇和正常非孕女性（P<0.05）。根据文献，子痫前期女性存在血容量减少。然而，在我们的研究组中并未证实这一点。
子痫前期女性的ANP水平高于血压正常的孕妇。其病因仍不清楚。
