Pain Medicine, UT MD Anderson Cancer Center, 1400 Holcombe Blvd, Unit 409, Houston, TX 77030.
University of Ilorin, Ilorin, Nigeria.
PM R. 2018 Apr;10(4):442-445. doi: 10.1016/j.pmrj.2017.08.439. Epub 2017 Sep 1.
Cancer pain management is comprehensive, and it generally begins with pharmacotherapy in a step-wise approach per analgesic guidelines established decades ago by the World Health Organization. This analgesic ladder involves the prescribing of co-analgesics, adjuvants, and opioids, with each step depending on pain severity. Although the majority of cancer pain responds to this strategy, there exist patients who do not respond adequately or experience significant side effects or intolerance to pain medications. It is in these patients whom clinicians consider interventional approaches. One approach to manage unremitting unilateral malignant pain includes evaluation for cordotomy, which is an approach that has been effective in such cases. We present a patient with breast cancer metastatic to the pelvis, with associated severe pelvic and right lower limb pain. Due to progressive disease, her pain worsened despite aggressive opioid dose escalations. She ultimately underwent percutaneous left anterolateral cervical cordotomy for malignant right leg pain, resulting in complete resolution of leg pain. We propose that, in select patients with neoplasm-related pain, cordotomy may prove very effective.
V.
未加标签:癌症疼痛管理是全面的,通常从根据世界卫生组织几十年前制定的镇痛指南逐步进行药物治疗开始。这个镇痛阶梯涉及到联合使用镇痛药、辅助药物和阿片类药物,每一步都取决于疼痛的严重程度。尽管大多数癌症疼痛对这种策略有反应,但仍存在一些患者对疼痛药物反应不足或出现严重副作用或不耐受。在这些患者中,临床医生会考虑介入治疗方法。一种管理持续单侧恶性疼痛的方法包括评估脊髓切开术,这种方法在这种情况下是有效的。我们介绍了一位患有转移性乳腺癌至骨盆的患者,伴有严重的骨盆和右下肢疼痛。由于疾病进展,尽管积极增加阿片类药物剂量,她的疼痛仍恶化。她最终接受了经皮左前外侧颈脊髓切开术治疗恶性右腿疼痛,导致右腿疼痛完全缓解。我们提出,对于某些与肿瘤相关的疼痛患者,脊髓切开术可能非常有效。
证据水平:V。