Hu Jiafen, Cladel Nancy M, Budgeon Lynn R, Balogh Karla K, Christensen Neil D
The Jake Gittlen Laboratories for Cancer Research, Hershey, PA 17033, USA.
Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Viruses. 2017 Aug 30;9(9):246. doi: 10.3390/v9090246.
The mouse papillomavirus (MmuPV1) was first reported in 2011 and has since become a powerful research tool. Through collective efforts from different groups, significant progress has been made in the understanding of molecular, virological, and immunological mechanisms of MmuPV1 infections in both immunocompromised and immunocompetent hosts. This mouse papillomavirus provides, for the first time, the opportunity to study papillomavirus infections in the context of a small common laboratory animal for which abundant reagents are available and for which many strains exist. The model is a major step forward in the study of papillomavirus disease and pathology. In this review, we summarize studies using MmuPV1 over the past six years and share our perspectives on the value of this unique model system. Specifically, we discuss viral pathogenesis in cutaneous and mucosal tissues as well as in different mouse strains, immune responses to the virus, and local host-restricted factors that may be involved in MmuPV1 infections and associated disease progression.
小鼠乳头瘤病毒（MmuPV1）于2011年首次被报道，此后成为一种强大的研究工具。通过不同团队的共同努力，在理解免疫受损和免疫健全宿主中MmuPV1感染的分子、病毒学和免疫学机制方面取得了重大进展。这种小鼠乳头瘤病毒首次提供了在一种小型常见实验动物的背景下研究乳头瘤病毒感染的机会，这种动物有丰富的试剂可用，并且存在许多品系。该模型在乳头瘤病毒疾病和病理学研究方面向前迈出了重要一步。在这篇综述中，我们总结了过去六年使用MmuPV1的研究，并分享我们对这个独特模型系统价值的看法。具体而言，我们讨论了皮肤和黏膜组织以及不同小鼠品系中的病毒发病机制、对该病毒的免疫反应，以及可能参与MmuPV1感染和相关疾病进展的局部宿主限制因素。
