Wang Arthur, Wainwright John V, Amin Anubhav G, Vail Eric, Silverstein Rachel, Das Kaushik
Department of Neurological Surgery, New York Medical College, Westchester, New York, USA.
Department of Pathology, New York Medical College, Westchester, New York, USA.
Case Rep Oncol. 2017 Jul 7;10(2):596-604. doi: 10.1159/000477845. eCollection 2017 May-Aug.
Sinonasal undifferentiated carcinoma (SNUC) is a rare malignancy of the upper airways and anterior skull base that carries a poor prognosis. The tumor is known to be invasive into the surrounding structures of the skull base and brain. To date, there is only one existing case report documenting drop metastasis to the intradural extramedullary spinal cord. To the best of our knowledge, we present the second case of metastatic SNUC to the spine. This report describes a 59-year-old male with a history of head and neck SNUC who presented with thoracic back pain and bilateral lower extremity paresis. Neuroimaging demonstrated an extradural thoracic mass with severe spinal cord compression. The patient underwent thoracic laminectomy and fusion for decompression of the spinal cord and internal stabilization. The pathology returned as SNUC. The patient was subsequently lost to follow-up from our institution. Metastatic SNUC is rare. We discuss the relevant clinical imaging and review the literature. Such a malignancy portends a very poor prognosis.
鼻窦未分化癌(SNUC)是上呼吸道和前颅底的一种罕见恶性肿瘤,预后较差。已知该肿瘤会侵犯颅底和脑部的周围结构。迄今为止,仅有一例现有病例报告记录了向硬脊膜外髓外脊髓的远处转移。据我们所知,我们报告了第二例转移至脊柱的SNUC病例。本报告描述了一名59岁男性,有头颈部SNUC病史,出现胸背部疼痛和双侧下肢无力。神经影像学显示硬脊膜外胸段肿块伴严重脊髓压迫。患者接受了胸椎椎板切除术和融合术以解除脊髓压迫并进行内固定。病理结果回报为SNUC。该患者随后失去了我们机构的随访。转移性SNUC很罕见。我们讨论相关临床影像学并复习文献。这种恶性肿瘤预后非常差。