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不同病理类型的串联性胸段脊髓病变:紧邻硬脊膜内脑膜瘤的同时性肺腺癌转移瘤病变

Tandem Thoracic Spinal Cord Lesions of Differing Pathologies: Concurrent Metastatic Lung Adenocarcinoma Lesion in Close Proximity to a Intradural Meningioma.

作者信息

Rai Shawn S, Goulart Carlos, Gokaslan Ziya, Galgano Michael

机构信息

Neurosurgery, State University of New York Upstate Medical University, Syracuse, USA.

Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, USA.

出版信息

Cureus. 2020 Jan 13;12(1):e6646. doi: 10.7759/cureus.6646.

DOI:10.7759/cureus.6646
PMID:32076582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7015116/
Abstract

Simultaneously having two pathologically distinct neoplastic lesions causing critical spinal stenosis is exceedingly rare. When such lesions are near one another but occupy different spinal compartments, significant challenges arise. We present the case of a patient with metastatic non-small cell carcinoma to the thoracic spine and an intradural meningioma occurring two spinal segments from each other. A 66-year-old female presented with one month of progressive mechanical back pain and two days of lower extremity weakness and urinary retention. She was found to have a left upper lobe lung mass. An urgent biopsy demonstrated non-small cell lung carcinoma. MRI of her thoracic spine demonstrated a T9 intradural-extramedullary enhancing lesion simultaneously with a destructive lesion of the T11 vertebral body extending into the anterior epidural space with significant cord compression at T9 and T11. The patient was taken for an urgent posterior decompression from T9 to T11, T9 left-sided pediculectomy with resection of intradural tumor, T11 corpectomy with anterior cage reconstruction, and instrumented fixation from T7 to L2. The pathology from the T9 lesion demonstrated findings consistent with a meningioma while the T11 lesion confirmed metastatic non-small cell lung adenocarcinoma. The patient improved neurologically postoperatively and regained the ability to ambulate within one week of surgery. Pathologically distinct spinal lesions in close anatomic proximity, but in two separate compartments are exceptionally rare. We performed a simultaneous posterior approach for resection of the T9 meningioma and a T11 corpectomy for the metastatic lesion with rapid neurologic recovery.

摘要

同时存在两个病理特征截然不同且导致严重脊髓狭窄的肿瘤性病变极为罕见。当这些病变彼此相邻但占据不同的脊髓腔室时,就会出现重大挑战。我们报告一例患者,其胸椎有转移性非小细胞癌,硬膜内有一个脑膜瘤,二者相隔两个脊髓节段。一名66岁女性因进行性机械性背痛1个月、下肢无力和尿潴留2天前来就诊。发现她左肺上叶有肿块。紧急活检显示为非小细胞肺癌。其胸椎MRI显示T9节段有硬膜内髓外强化病变,同时T11椎体有破坏性病变,延伸至硬膜前间隙,T9和T11节段脊髓受压明显。患者接受了从T9至T11的紧急后路减压、T9左侧椎弓根切除术及硬膜内肿瘤切除术、T11椎体次全切除术及前路椎间融合器重建术,以及从T7至L2的器械固定术。T9病变的病理结果显示符合脑膜瘤,而T11病变证实为转移性非小细胞肺腺癌。患者术后神经功能改善,术后一周内恢复了行走能力。解剖位置相近但位于两个不同腔室的病理特征截然不同的脊柱病变极为罕见。我们采用同时后路入路切除T9脑膜瘤和对转移性病变进行T11椎体次全切除术,患者神经功能恢复迅速。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/4caf1112f318/cureus-0012-00000006646-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/37cf5cfbff27/cureus-0012-00000006646-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/b8c77ac4a821/cureus-0012-00000006646-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/69ac95015ffc/cureus-0012-00000006646-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/4caf1112f318/cureus-0012-00000006646-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/37cf5cfbff27/cureus-0012-00000006646-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/b8c77ac4a821/cureus-0012-00000006646-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/69ac95015ffc/cureus-0012-00000006646-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e83/7015116/4caf1112f318/cureus-0012-00000006646-i04.jpg

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