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E选择素和基质细胞衍生因子-1调节乳腺癌细胞在骨内的转移运输。

E-Selectin and SDF-1 regulate metastatic trafficking of breast cancer cells within the bone.

作者信息

Price Trevor T, Sipkins Dorothy A

机构信息

Division of Hematologic Malignancies and Cellular Therapy, Department of Medicine, Duke University, Durham, USA.

出版信息

Mol Cell Oncol. 2016 Jul 26;4(4):e1214771. doi: 10.1080/23723556.2016.1214771. eCollection 2017.

DOI:10.1080/23723556.2016.1214771
PMID:28868340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5540205/
Abstract

E-selectin is a key mediator of breast cancer cell (BCC) metastatic entry into the bone and stromal-derived factor 1 (SDF-1) is a critical molecular anchor for BCCs within discrete pro-dormancy bone marrow (BM) niches. Small-molecule inhibitors blocked metastatic entry and mobilized established disease from BM, suggesting a new treatment strategy to prevent breast cancer relapse.

摘要

E选择素是乳腺癌细胞（BCC）转移进入骨骼的关键介质，而基质衍生因子1（SDF-1）是离散的前休眠骨髓（BM）龛内BCC的关键分子锚定物。小分子抑制剂可阻断转移进入并从骨髓中动员已形成的疾病，提示了一种预防乳腺癌复发的新治疗策略。

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Mol Cell Oncol. 2016 Jul 26;4(4):e1214771. doi: 10.1080/23723556.2016.1214771. eCollection 2017.
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本文引用的文献

1
Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone.休眠的乳腺癌微转移灶存在于特定的骨髓微环境中，这些微环境调节着它们进出骨骼的转移过程。
Sci Transl Med. 2016 May 25;8(340):340ra73. doi: 10.1126/scitranslmed.aad4059.
2
A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.原发性肿瘤中上皮-间质可塑性和基质激活的特征独立于疾病亚型调节乳腺癌的晚期复发。
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Global cancer statistics.全球癌症统计数据。
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Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT).间质干细胞（MSCs）在乳腺肿瘤微环境中的潜在作用：刺激上皮间质转化（EMT）。
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Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma.普乐沙福与粒细胞集落刺激因子对比安慰剂与粒细胞集落刺激因子用于动员多发性骨髓瘤患者造血干细胞以进行自体干细胞移植
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A pooled analysis of bone marrow micrometastasis in breast cancer.乳腺癌骨髓微转移的汇总分析。
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Nature. 2005 Jun 16;435(7044):969-73. doi: 10.1038/nature03703.
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