细胞黏附分子在激素相关癌症中的作用机制：简要展望。

Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Department of Endocrinology, Affiliated Baoan Hospital of Shenzhen, Southern Medical University, Shenzhen, China.

Front Endocrinol (Lausanne). 2022 Apr 7;13:865436. doi: 10.3389/fendo.2022.865436. eCollection 2022.

Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment cell adhesion molecules (CAMs) promotes drug resistance, known as cell adhesion-mediated drug resistance (CAM-DR). CAMs are cell surface molecules that facilitate cell-to-cell or cell-to-extracellular matrix binding. CAMs exert an adhesion effect and trigger intracellular signaling that regulates cancer cell stemness maintenance, survival, proliferation, metastasis, epithelial-mesenchymal transition, and drug resistance. To understand these mechanisms, this review focuses on the role of CD44, cadherins, selectins, and integrins in CAM-DR in endocrine-related cancers.

化疗是内分泌相关癌症的重要治疗方法；然而，化疗耐药和疾病复发仍然是一个挑战。癌细胞与肿瘤微环境细胞黏附分子（CAMs）之间的相互作用促进了耐药性的产生，这种现象被称为细胞黏附介导的耐药性（CAM-DR）。CAMs 是细胞表面分子，可促进细胞间或细胞与细胞外基质的结合。CAMs 发挥黏附作用，并触发细胞内信号转导，调节癌细胞干性维持、存活、增殖、转移、上皮-间充质转化和耐药性。为了理解这些机制，本综述重点关注 CD44、钙黏蛋白、选择素和整合素在内分泌相关癌症的 CAM-DR 中的作用。