Yan Sheng-Yi, Zhang Zhuo-Zhuo, Shi Bing-Feng
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
Chem Commun (Camb). 2017 Sep 14;53(74):10287-10290. doi: 10.1039/c7cc05532c.
A highly selective nickel-catalyzed C-H trifluoroethylation of heteroarenes was developed with the assistance of a monodentate directing group. This protocol provides efficient access to various trifluoroethyl-substituted heteroarenes, including indoles, pyrroles, furans, and thiophenes, with commercially available CFCHI as an alkylation reagent. This robust catalytic procedure is scalable and tolerates a broad range of functional groups. Moreover, multifluoroalkylation of indoles is also viable.
在单齿导向基团的辅助下，开发了一种高度选择性的镍催化杂芳烃C-H三氟乙基化反应。该方法以市售的CFCHI作为烷基化试剂，能有效合成各种三氟乙基取代的杂芳烃，包括吲哚、吡咯、呋喃和噻吩。这种稳健的催化方法具有可扩展性，并且能耐受多种官能团。此外，吲哚的多氟烷基化也是可行的。
