Shi Xiaolin, Li Xiaowei, Li Xiangqian, Shi Dayong
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Front Chem. 2019 Sep 6;7:613. doi: 10.3389/fchem.2019.00613. eCollection 2019.
A highly selective copper-catalyzed trifluoromethylation of indoles is reported with the assistance of a removable directing group. This protocol provides an easy and rapid method to various 2-position-selective trifluoromethylated heteroarenes including indoles, pyrroles, benzofuran, and acetanilide. What is more, the reaction takes place at ambient conditions without any external ligand or additive.
据报道，在可移除导向基团的辅助下实现了吲哚的高选择性铜催化三氟甲基化反应。该方法为合成包括吲哚、吡咯、苯并呋喃和乙酰苯胺在内的各种2-位选择性三氟甲基化杂芳烃提供了一种简便快捷的方法。此外，该反应在环境条件下进行，无需任何外部配体或添加剂。
