Zhao Kai, Zhang Ze-Yu, Cui Xian-Lu, Wang Ying-Xue, Wu Xian-Dan, Li Wei-Ming, Wu Jia-Xu, Zhao Li-Li, Guo Jing-Yu, Loh Teck-Peng
Institute of Advanced Synthesis, Technical Institute of Fluorochemistry, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Org Lett. 2020 Nov 20;22(22):9029-9035. doi: 10.1021/acs.orglett.0c03418. Epub 2020 Nov 11.
A photoredox-catalyzed regio- and stereoselective trifluoroethylation reaction of enamides using commercially available 2,2,2-trifluoroethyl iodide as trifluoroethylating agents has been developed, furnishing geometrically defined and synthetically and physiochemically pivotal β-trifluoroethylated enamides bearing a diverse range of functional groups.
利用市售的2,2,2-三氟乙基碘作为三氟乙基化试剂，开发了一种光氧化还原催化的烯酰胺区域和立体选择性三氟乙基化反应，得到了具有多种官能团、几何结构明确且在合成及物理化学方面具有关键意义的β-三氟乙基化烯酰胺。
