Landry Latrice, Nielsen Daiva Elena, Carere Deanna Alexis, Roberts J Scott, Green Robert C
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
J Community Genet. 2017 Oct;8(4):293-301. doi: 10.1007/s12687-017-0325-5. Epub 2017 Sep 4.
There is little information regarding direct-to-consumer (DTC) personal genetic testing (PGT) in non-White racial minorities. Using a web-based survey, we compared the pretest interests and attitudes toward DTC-PGT of racial minority and White DTC-PGT customers of 23andMe and Pathway Genomics using chi-square tests and multinomial regression. Data were available for 1487 participants (1389 White, 44 Black, and 54 Asian). Survey responses were similar across racial groups, although a greater proportion of Blacks compared to Whites reported being "very interested" in genetic information related to traits (91.9 vs. 70.8%, p = 0.009). A greater proportion of Asians compared to Whites reported that a "very important" consideration for pursuing DTC-PGT was limited information about their family health history (58.0 vs. 37.5%, p = 0.002). While a number of significant differences between groups were observed in unadjusted analyses, they did not remain significant after adjustment. This study provides a preliminary view of the interests for purchasing DTC-PGT among customers with racial minority backgrounds.
关于非白人少数族裔直接面向消费者（DTC）的个人基因检测（PGT）的信息很少。我们通过一项基于网络的调查，使用卡方检验和多项回归比较了少数族裔和23andMe及Pathway Genomics的白人DTC-PGT客户在检测前对DTC-PGT的兴趣和态度。共有1487名参与者的数据可供分析（1389名白人、44名黑人、54名亚洲人）。不同种族群体的调查回复相似，不过与白人相比，更大比例的黑人表示对与性状相关的基因信息“非常感兴趣”（91.9%对70.8%，p = 0.009）。与白人相比，更大比例的亚洲人表示进行DTC-PGT的“一个非常重要”的考虑因素是关于其家族健康史的信息有限（58.0%对37.5%，p = 0.002）。虽然在未经调整的分析中观察到了组间的一些显著差异，但调整后这些差异不再显著。本研究初步呈现了少数族裔背景客户购买DTC-PGT的兴趣情况。
