Epi-Centre for Healthy Ageing, IMPACT SRC, School of Medicine, Deakin University (Barwon Health), PO Box 281, Geelong, VIC, 3220, Australia.
Institute for Health and Ageing, Australian Catholic University, Melbourne, VIC, Australia.
Osteoporos Int. 2017 Dec;28(12):3407-3414. doi: 10.1007/s00198-017-4208-8. Epub 2017 Sep 3.
No studies have explored the relationship with maternal vitamin D (25(OH)D) in pregnancy and offspring trabecular bone score (TBS). Our data suggest that maternal 25(OH)D in early pregnancy, but not late, may be associated with offspring TBS in boys. These data act as hypothesis-generating findings for confirmation in larger, longer-term studies.
Trabecular bone score (TBS), a novel tool derived from dual-energy X-ray absorptiometry (DXA), reflects the microarchitecture of the vertebrae. It has been shown to predict fracture independent of standard DXA parameters in adult populations. Previously, we demonstrated that maternal serum 25-hydroxyvitamin D (25(OH)D) during pregnancy is associated with offspring bone mineral content at age 11 years. However, associations with TBS have not been explored, thus we aimed to determine associations between maternal 25(OH)D and offspring TBS.
Data were collected from the Vitamin D in Pregnancy (VIP) study. Venous blood samples were taken at recruitment and at 28-32 weeks' gestation. Maternal 25(OH)D was measured by radioimmunoassay. Offspring (n = 195, n = 181 with complete measures) underwent spine DXA (GE Lunar), at age 11 years (median = 10.9 (IQR 10.9-11.4)). TBS was calculated using TBS iNsight software.
Offspring of mothers with sufficient 25(OH)D levels (≥50 nmol/L) at recruitment had a higher TBS (1.363 vs. 1.340, p = 0.04). In multivariable linear regression models, after adjustment for child relative lean mass, sex and pubertal stage, a 10 nmol/L increase in maternal 25(OH)D was associated with a 0.005 (95% CI 0.000, 0.010, p = 0.04) increase in TBS. However when stratified by sex (p for interaction = 0.16), the association was significant in boys, but not girls. There were no associations with TBS and maternal 25(OH)D at 28-32 weeks.
We speculate that maternal 25(OH)D in early pregnancy may be associated with TBS in offspring at age 11 in boys. These hypothesis-generating findings warrant confirmation with larger interventional and long-term follow-up studies.
未研究过妊娠期间母体维生素 D（25（OH）D）与后代小梁骨评分（TBS）之间的关系。我们的数据表明，妊娠早期而非晚期的母体 25（OH）D 可能与男孩的后代 TBS 相关。这些数据为在更大、更长期的研究中进一步证实提供了假设生成的发现。
小梁骨评分（TBS）是一种源自双能 X 射线吸收法（DXA）的新型工具，反映了椎体的微观结构。在成年人群中，它已被证明可独立于标准 DXA 参数预测骨折。此前，我们证明了妊娠期间母体血清 25-羟维生素 D（25（OH）D）与 11 岁儿童的后代骨矿物质含量有关。但是，尚未探讨与 TBS 的关系，因此我们旨在确定母体 25（OH）D 与后代 TBS 之间的关系。
数据来自维生素 D 妊娠研究（VIP）。在招募时和 28-32 周妊娠时采集静脉血样。通过放射免疫分析法测量母体 25（OH）D。11 岁时（中位数=10.9（IQR 10.9-11.4）），对 195 名后代（n=181 名有完整测量值）进行了脊柱 DXA（GE 月球仪）检查。使用 TBS iNsight 软件计算 TBS。
招募时母体 25（OH）D 水平足够（≥50 nmol/L）的后代 TBS 更高（1.363 比 1.340，p=0.04）。在多变量线性回归模型中，在校正儿童相对瘦体重、性别和青春期阶段后，母体 25（OH）D 增加 10 nmol/L，TBS 增加 0.005（95%CI 0.000，0.010，p=0.04）。但是按性别分层（p 交互作用=0.16），该关联在男孩中显著，而在女孩中不显著。母体 25（OH）D 与妊娠 28-32 周时的 TBS 无关联。
我们推测，妊娠早期母体 25（OH）D 可能与男孩 11 岁时的后代 TBS 相关。这些假设生成的发现需要更大的干预和长期随访研究来证实。
