Potter W Z, Rudorfer M V, Pickar D, Linnoila M
Life Sci. 1987 Aug 17;41(7):817-20. doi: 10.1016/0024-3205(87)90170-6.
Primary biochemical profiles of antidepressants and neuroleptics are summarized in comparison to their actual effects on monoamine neurotransmitters in humans during the time period when clinical response emerges. Even the most biochemically specific of these drugs produces effects on at least two monoamines by three to four weeks. Interestingly, taking into account relative changes in dopamine and serotonin metabolites in cerebrospinal fluid relates better to the primary biochemical action(s) of each drug than do absolute changes. Moreover, monoamine changes after drugs are in the opposite direction to those after ECT, suggesting that balance among rather than shifts in single neurotransmitters is the relevant target of major psychotropic drugs.
本文总结了抗抑郁药和抗精神病药的主要生化特征，并将其与临床反应出现期间这些药物对人类单胺类神经递质的实际作用进行了比较。即使是这些药物中生化特异性最高的药物，在三到四周内也会对至少两种单胺产生作用。有趣的是，考虑到脑脊液中多巴胺和血清素代谢物的相对变化，比绝对变化更能反映每种药物的主要生化作用。此外，药物作用后的单胺变化方向与ECT后的相反，这表明主要精神药物的相关靶点是单一神经递质之间的平衡，而非其变化。
