1 Department of Cardiology, VU University Medical Center, Amsterdam, The Netherlands.
2 Institute of Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
Eur Heart J Acute Cardiovasc Care. 2019 Feb;8(1):45-53. doi: 10.1177/2048872617728559. Epub 2017 Sep 4.
In the past few decades, cardiac ultrasound has become a widely available, easy-to-use diagnostic tool in many scenarios in acute cardiac care. The introduction of microbubbles extended its diagnostic value. Not long thereafter, several investigators explored the therapeutic potential of contrast ultrasound on thrombus dissolution. Despite large improvements in therapeutic options, acute ST elevation myocardial infarction remains one of the main causes of mortality and morbidity in the western world. The therapeutic effect of contrast ultrasound on thrombus dissolution might prove to be a new, effective treatment strategy in this group of patients. With the recent publication of human studies scrutinising the therapeutic options of ultrasound and microbubbles in ST elevation myocardial infarction, we have entered a new stage in this area of research. This therapeutic effect is based on biochemical effects both at macrovascular and microvascular levels, of which the exact working mechanisms remain to be elucidated in full. This review will give an up-to-date summary of our current knowledge of the therapeutic effects of contrast ultrasound and its potential application in the field of ST elevation myocardial infarction, along with its future developments.
在过去几十年中，心脏超声已成为急性心脏护理中许多情况下广泛可用、易于使用的诊断工具。微泡的引入扩展了其诊断价值。此后不久，几位研究人员就对比超声在血栓溶解方面的治疗潜力进行了探索。尽管治疗选择有了很大的改进，但急性 ST 段抬高型心肌梗死仍然是西方世界死亡率和发病率的主要原因之一。对比超声对血栓溶解的治疗效果可能被证明是这群患者的一种新的、有效的治疗策略。随着最近发表的研究人类研究，对超声和微泡在 ST 段抬高型心肌梗死中的治疗选择进行了审查，我们已经进入了该研究领域的一个新阶段。这种治疗效果基于宏观和微观水平的生化效应，其确切的工作机制仍有待充分阐明。这篇综述将最新总结我们目前对比超声的治疗效果及其在 ST 段抬高型心肌梗死领域的潜在应用的认识，以及它的未来发展。
