从尖叶假龙胆中分离出的氧杂蒽酮及其对过氧化氢诱导的心肌细胞损伤的保护作用。
Xanthones isolated from Gentianella acuta and their protective effects against HO-induced myocardial cell injury.
作者信息
Wang Zhibin, Wu Gaosong, Yu Ying, Liu Hua, Yang Bingyou, Kuang Haixue, Wang Qiuhong
机构信息
a Key Laboratory of Chinese Materia Medica (Ministry of Education) , Heilongjiang University of Chinese Medicine , Harbin , China.
b School of Traditional Chinese Medicine , Guangdong Pharmaceutical University , Guangzhou , China.
出版信息
Nat Prod Res. 2018 Sep;32(18):2171-2177. doi: 10.1080/14786419.2017.1371157. Epub 2017 Sep 4.
In the present study, two new xanthones, (5'S,8'S)-1,3,5,8-tetrahydroxyxanthone(7→2')-1,3,5,8-tetrahydroxy-5',6',7',8'-tetrahydroxanthone (1), 5-hydroxy-3,4,6-trimethoxyxanthone-1-O-β-D-glucopyranoside (2), and eight known xanthones (3-10) were isolated from the whole plants of Gentianella acuta. Their structures were identified by the spectroscopic analyses (HR-ESI-MS, and 1D and 2D NMR). Meanwhile, cell-protective effects against HO-induced H9c2 cardiomyocyte injury and cytotoxic activities of compounds 1-10 were also determined.
在本研究中，从尖叶假龙胆全草中分离得到两个新的呫吨酮，即(5'S,8'S)-1,3,5,8-四羟基呫吨酮(7→2')-1,3,5,8-四羟基-5',6',7',8'-四羟基呫吨酮(1)、5-羟基-3,4,6-三甲氧基呫吨酮-1-O-β-D-吡喃葡萄糖苷(2)，以及八个已知的呫吨酮(3 - 10)。通过光谱分析(高分辨电喷雾电离质谱以及一维和二维核磁共振)确定了它们的结构。同时，还测定了化合物1 - 10对过氧化氢诱导的H9c2心肌细胞损伤的细胞保护作用和细胞毒性活性。
Zotero 插件