Ding Zhijuan, Liu Yanxia, Ruan Jingya, Yang Shengcai, Yu Haiyang, Chen Meiling, Zhang Yi, Wang Tao
Tianjin State Key Laboratory of Modern Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China.
Molecules. 2017 Aug 6;22(8):1309. doi: 10.3390/molecules22081309.
As a Mongolian native medicine and Ewenki folk medicinal plant, has been widely used for the treatment of diarrhea, hepatitis, arrhythmia, and coronary heart disease. In the course of investigating efficacy compounds to treat diarrhea using a mouse isolated intestine tissue model, we found 70% EtOH extract of whole plants had an inhibitory effect on intestine contraction tension. Here, nineteen constituents, including five new compounds, named as gentiiridosides A (), B (), gentilignanoside A (), (1)-2,2,3-trimethyl-4-hydroxymethylcyclopent-3-ene-1-methyl--β-d-glucopyranoside (), and (3)-3-hexene-1,5-diol 1--α-l-arabinopyranosyl(1→6)-β-d-glucopyranoside () were obtained from it. The structures of them were elucidated by chemical and spectroscopic methods. Furthermore, the inhibitory effects on motility of mouse isolated intestine tissue of the above mentioned compounds and other thirteen iridoid- and secoiridoid-type monoterpenes (-, -, , , , , and ) previously obtained in the plant were analyzed. As results, new compound , some secoiridoid-type monoterpenes , , -, , and , as well as 7--9'-type lignans and displayed significant inhibitory effect on contraction tension at 40 μM.
作为一种蒙药和鄂温克族民间药用植物，[植物名称未给出]已被广泛用于治疗腹泻、肝炎、心律失常和冠心病。在使用小鼠离体肠组织模型研究治疗腹泻的有效化合物的过程中，我们发现该植物全株70%乙醇提取物对肠收缩张力有抑制作用。在此，从该植物中获得了19种成分，包括5种新化合物，分别命名为龙胆苦苷A（[具体结构未给出]）、B（[具体结构未给出]）、龙胆木脂苷A（[具体结构未给出]）、(1)-2,2,3-三甲基-4-羟甲基环戊-3-烯-1-甲基-β-D-吡喃葡萄糖苷（[具体结构未给出]）和(3)-3-己烯-1,5-二醇1-α-L-阿拉伯吡喃糖基(1→6)-β-D-吡喃葡萄糖苷（[具体结构未给出]）。通过化学和光谱方法阐明了它们的结构。此外，还分析了上述化合物以及该植物中先前获得的其他13种环烯醚萜和裂环环烯醚萜型单萜（[具体化合物名称未给出]）对小鼠离体肠组织运动的抑制作用。结果表明，新化合物[具体化合物名称未给出]、一些裂环环烯醚萜型单萜[具体化合物名称未给出]、[具体化合物名称未给出]、[具体化合物名称未给出]、[具体化合物名称未给出]和[具体化合物名称未给出]，以及7-O-9'-型木脂素[具体化合物名称未给出]和[具体化合物名称未给出]在40μM时对收缩张力显示出显著的抑制作用。
