Unit of Obstetrics, Gynecology, Department of Biomedical, Clinical Sciences, ASST Fatebenefratelli Sacco, Hospital "L. Sacco" via GB Grassi 74, Milan, Italy, Centre for Fetal Research Giorgio Pardi.
Departments of Biomedical and Clinical Sciences Luigi Sacco, Italy.
Magnes Res. 2017 May 1;30(2):35-41. doi: 10.1684/mrh.2017.0421.
Magnesium (Mg) and calcium (Ca) are essential cations for women's preconception health. It is well known that, in blood, the concentration of ionized form of these two cations is temporally altered during menstrual cycle, suggesting a correlation between sex steroid hormones and serum calcium and magnesium levels. Evidence from literature suggests that in assisted reproductive technology increasing estrogens during ovarian hyperstimulation may also modulate serum magnesium and calcium levels. Therefore, we first examined total serum magnesium and calcium levels during follicular phase in a large population of infertile patients who underwent intrauterine insemination (IUI). The results were compared to a group of fertile women. Successively, we studied the total serum magnesium and calcium concentrations in infertile patients before and after ovarian hyperstimulation for in vitro fertilization (IVF). Results highlight that total serum concentration of magnesium and calcium does not seem altered in infertile women. During stimulation with gonadotropins, the values of the two cations do not change significantly in ovarian-stimulated women. However, we found a downward trend in the total magnesium and calcium levels in relation to the rising estrogens.
镁（Mg）和钙（Ca）是女性孕前健康的必需阳离子。众所周知，在血液中，这两种阳离子的离子形式浓度在月经周期中会发生暂时变化，提示性激素和血清钙镁水平之间存在相关性。文献中的证据表明，在辅助生殖技术中，卵巢过度刺激期间增加雌激素也可能调节血清镁和钙水平。因此，我们首先在接受宫腔内人工授精（IUI）的大量不孕患者的卵泡期检查了总血清镁和钙水平。将结果与一组生育能力正常的女性进行了比较。随后，我们研究了体外受精（IVF）前卵巢过度刺激前后不孕患者的总血清镁和钙浓度。结果表明，不孕妇女的总血清镁和钙浓度似乎没有改变。在促性腺激素刺激期间，两种阳离子的浓度在卵巢刺激的女性中没有显著变化。然而，我们发现总镁和钙水平与雌激素的升高呈下降趋势。
