Tian Sicong, Liu Xiaodong, Lei Peng, Zhang Xiaohong, Shan Yujuan
Department of Food Science and Engineering, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China.
Institute of Preventative Medicine and Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, School of Medicine, Ningbo University, Zhejiang, China.
J Sci Food Agric. 2018 Mar;98(4):1255-1260. doi: 10.1002/jsfa.8654. Epub 2017 Oct 9.
Isothiocyanates (ITCs), such as sulforaphane (SFN), exhibit powerful biological functions in fighting cancers, and cardiovascular and neurodegenerative diseases. They normally exist as glucosinolates (GLSs) in cruciferous vegetables, which are not themselves bioactive until they are degraded by myrosinase to form ITCs. Myrosinase coexists in the same plants but is normally kept apart from GLSs in different apparatus. A key point is that myrosinase is temperature sensitive and can be inactivated upon exposure to temperatures over 60 °, as typically occurs during cooking. However, studies using animal models and population trials have suggested that human gut bacteria might act like an 'organ' in that they can secrete their own myrosinase. In this review, the hydrolysis of GLS by myrosinase is discussed, with an important focus on the gut microflora and their myrosinase-producing roles. © 2017 Society of Chemical Industry.
异硫氰酸盐（ITCs），如萝卜硫素（SFN），在对抗癌症、心血管疾病和神经退行性疾病方面具有强大的生物学功能。它们通常以硫代葡萄糖苷（GLSs）的形式存在于十字花科蔬菜中，在被黑芥子酶降解形成ITCs之前，它们本身没有生物活性。黑芥子酶与硫代葡萄糖苷共存于同一植物中，但通常在不同的细胞器中彼此分离。关键在于黑芥子酶对温度敏感，暴露于60℃以上的温度时会失活，烹饪过程中通常就会出现这种情况。然而，使用动物模型和人群试验的研究表明，人类肠道细菌可能起到“器官”的作用，因为它们可以分泌自身的黑芥子酶。在这篇综述中，我们讨论了黑芥子酶对硫代葡萄糖苷的水解作用，重点关注肠道微生物群及其产生黑芥子酶的作用。© 2017化学工业协会。
