Iyer K S, McCann S M
Neuroendocrinology. 1987 Jun;46(1):93-5. doi: 10.1159/000124802.
Delta sleep inducing peptide (DSIP) has been localized in the rat hypothalamus. The effect of DSIP on somatostatin (SRIF) release from the median eminence of the hypothalamus was evaluated in male and female rats in an in vitro incubation system. DSIP inhibited SRIF release in a dose-dependent manner. The median eminences from females were less sensitive to the inhibitory action of DSIP than those of males; however, in both sexes the maximum effect was observed at a concentration of 10(-8) M DSIP. This effect was blocked by addition of pimozide at a concentration of 10(-6) M. Pimozide alone had no effect on SRIF release. These findings lead to the conclusion that DSIP inhibits SRIF release via a dopaminergic mechanism.
δ-睡眠诱导肽（DSIP）已定位在大鼠下丘脑。在体外孵育系统中，评估了DSIP对雄性和雌性大鼠下丘脑正中隆起生长抑素（SRIF）释放的影响。DSIP以剂量依赖性方式抑制SRIF释放。雌性大鼠的正中隆起对DSIP的抑制作用比雄性大鼠的敏感性低；然而，在两性中，在DSIP浓度为10^(-8) M时观察到最大效应。加入浓度为10^(-6) M的匹莫齐特可阻断此效应。单独使用匹莫齐特对SRIF释放无影响。这些发现得出结论，DSIP通过多巴胺能机制抑制SRIF释放。
