Nakamura A, Nakashima M, Sugao T, Kanemoto H, Fukumura Y, Shiomi H
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan.
Eur J Pharmacol. 1988 Oct 18;155(3):247-53. doi: 10.1016/0014-2999(88)90510-9.
The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats. DSIP, administered intracerebroventricularly or intracisternally to mice, produced a significant dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests. Intrathecal administration of DSIP did not produce such an effect. The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist, naloxone. Moreover, DSIP did not produce an antinociceptive effect in morphine-tolerant mice. Similar antinociceptive effects of DSIP were observed in rats. These results suggest that DSIP produces an antinociceptive effect by acting at the supraspinal level and that this effect is mediated via the opioid receptor, either directly or indirectly. DSIP may play an important role in pain regulation in the central nervous system.
在小鼠和大鼠中评估了中枢给予δ-睡眠诱导肽（DSIP）对伤害性反应的影响。向小鼠脑室内或脑池内给予DSIP，在夹尾和热板试验中产生了显著的剂量依赖性镇痛作用。鞘内给予DSIP未产生这种作用。DSIP的镇痛作用被阿片类拮抗剂纳洛酮预处理所阻断。此外，DSIP在吗啡耐受的小鼠中未产生镇痛作用。在大鼠中观察到了DSIP类似的镇痛作用。这些结果表明，DSIP通过作用于脊髓上水平产生镇痛作用，并且这种作用是通过阿片受体直接或间接介导的。DSIP可能在中枢神经系统的疼痛调节中发挥重要作用。
