Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 EL Buhouth St., Dokki, Giza 12622, Egypt.
Applied Organic Chemistry Department, Chemical Industries Research Division, National Research Centre, 33 EL Buhouth St., Dokki, Giza 12622, Egypt.
J Pharm Biomed Anal. 2017 Nov 30;146:126-134. doi: 10.1016/j.jpba.2017.08.020. Epub 2017 Aug 26.
Isolation of bioactive compounds from extracts of pharmaceutical plant is very important. In this work, copper benzene-1,3,5-tricarboxylate metal organic framework (Cu-BTC MOF) has been synthesized. It is used in separating of chamazulene from chamomile extract. The Cu-BTC MOF not only shows good chamazulene adsorption but also maintains good desorption properties. However, the research on this field is still new and the maturation of novel MOFs or the enhancements of known ones are required.The chamomile extract obtained after each stage of the treatments was carefully characterized by thin-layer chromatography (TLC), Fourier-transform infrared spectroscopy (FTIR), UV-vis spectrometry and gas chromatography-mass spectrometry (GC-MS). The morphology and the crystallinity of Cu-BTC MOF were investigated using scanning electron microscopy (SEM) and powder X-ray diffraction (PXRD), respectively. Breakthrough experiments in a column was investigated and the data was fitted with Bohart-Adams model. Monte Carlo simulation was conducted to investigate the preferential adsorption sites of Cu-BTC for chamazulene molecules.
从药用植物提取物中分离生物活性化合物非常重要。在这项工作中，合成了铜苯-1,3,5-三甲酸金属有机骨架（Cu-BTC MOF）。它用于从甘菊提取物中分离蓝甘菊素。Cu-BTC MOF 不仅表现出良好的蓝甘菊素吸附性能，而且还保持良好的解吸性能。然而，该领域的研究仍处于起步阶段，需要新型 MOFs 的成熟或已知 MOFs 的增强。通过薄层色谱（TLC）、傅里叶变换红外光谱（FTIR）、紫外可见光谱和气相色谱-质谱（GC-MS）对每个处理阶段后的甘菊提取物进行了仔细的表征。使用扫描电子显微镜（SEM）和粉末 X 射线衍射（PXRD）分别研究了 Cu-BTC MOF 的形态和结晶度。通过柱穿透实验进行了研究，并使用 Bohart-Adams 模型对数据进行了拟合。进行了蒙特卡罗模拟，以研究 Cu-BTC 对蓝甘菊素分子的优先吸附位。
