Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA, CONICET, UNLP), Facultad de Ciencias Exactas, Departamento de Química, Universidad Nacional de La Plata, Casilla de Correo 16, Sucursal 4, 1900 La Plata, Argentina.
Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA, CONICET, UNLP), Facultad de Ciencias Exactas, Departamento de Química, Universidad Nacional de La Plata, Casilla de Correo 16, Sucursal 4, 1900 La Plata, Argentina; Facultad de Ingeniería, Universidad Nacional de La Plata, Calle 47 y 1, 1900 La Plata, Argentina.
Colloids Surf B Biointerfaces. 2017 Nov 1;159:673-683. doi: 10.1016/j.colsurfb.2017.08.029. Epub 2017 Aug 24.
With the intention of taking care of the environment and human health, the development of alternative eco-friendly methods to inhibit metal corrosion is intensively encouraged. In previous works we showed that some phytocompounds components of essential oils such as carvacrol (Carv) and thymol (TOH) are able to be electropolymerized on metals and they seem to be promissory for this purpose. The aim this paper is to investigate if the biocompatibility of copper covered by coatings formed by electropolymerization of Carv and TOH (polyCarv and polyTOH) is related with the potential selected for the electropolymerization process. Potentiostatic perturbations at different potentials, AFM images, ATR-FTIR spectroscopy and measurements of copper ions release provided suitable information to make a detailed analysis of different stages of the electropolymerization process that leads to polyCarv and polyTOH layers on copper surface. The change of the characteristics of the coatings over time was evaluated after several polymerization periods and current transients were interpreted by using nucleation and growth models. Results showed interesting changes in the polymerization process with the electrochemical perturbation, nature of the isomer, and time of the treatment. The treatment that provides the most protective, transparent and homogeneous layer, that strongly increased the biocompatibility of Cu could be selected: electropolymerization of Carv at 0.4V. Results highlight the importance of the detailed study of the evolution of the electropolymerization processes to select the best ecofriendly condition due the high impact of potential perturbation and polarization time on the biocompatibility of the resulting polymeric layer-copper system.
出于对环境和人类健康的关注，人们积极鼓励开发替代的环保方法来抑制金属腐蚀。在之前的工作中，我们已经证明，一些植物化合物（如香芹酚（Carv）和百里香酚（TOH））是精油的组成部分，能够在金属上进行电聚合，并且它们似乎在这方面很有前途。本文的目的是研究由 Carv 和 TOH 的电聚合（聚 Carv 和聚 TOH）形成的涂层覆盖的铜的生物相容性是否与电聚合过程中选择的电位有关。在不同电位下进行恒电位扰动、原子力显微镜图像、衰减全反射傅里叶变换红外光谱和铜离子释放测量，为详细分析导致铜表面聚 Carv 和聚 TOH 层的电聚合过程的不同阶段提供了合适的信息。在经过多个聚合周期后，评估了涂层随时间的特性变化，并通过使用成核和生长模型对电流瞬变进行了解释。结果表明，电化学扰动、异构体的性质和处理时间对聚合过程的变化有很大影响。可以选择提供最具保护性、透明度和均匀性的涂层的处理方法：在 0.4V 下进行 Carv 的电聚合。研究结果强调了详细研究电聚合过程演变的重要性，因为电位扰动和极化时间对所得聚合层-铜体系的生物相容性有很大影响，因此需要选择最佳的环保条件。
