Schechter M D
Pharmacol Biochem Behav. 1987 May;27(1):41-4. doi: 10.1016/0091-3057(87)90474-6.
Using a two-lever, food-motivated discrimination procedure, eight male rats were trained to discriminate 1.5 mg/kg of racemic 3,4-methylenedioxymethamphetamine (MDMA) from its vehicle, distilled water. Once trained, the rats demonstrated a dose-related decrease in discriminative performance after administration of lower doses of MDMA (ED50 = 0.27 mg/kg). Racemic MDMA-stimulus generalization occurred with both isomers of MDMA with the ED50 of the (+) isomer calculated as 0.50 mg/kg and for the (-) isomer being 1.07. Time-course data indicate that racemic MDMA has a peak effect from 20-60 min post-injection with a declining effect from 120-240 min. This time-course closely resembles that observed by subjective reports in human abusers and, together with previous data, would indicate that the discriminative paradigm would be useful in investigations as to the neurochemical effects of MDMA.
采用双杠杆、食物激励辨别程序，对8只雄性大鼠进行训练，使其能够区分1.5毫克/千克的外消旋3,4-亚甲基二氧甲基苯丙胺（摇头丸）与其溶剂蒸馏水。训练完成后，给予较低剂量的摇头丸（半数有效剂量[ED50]=0.27毫克/千克）后，大鼠的辨别能力出现与剂量相关的下降。外消旋摇头丸的刺激泛化现象在摇头丸的两种异构体中均有发生，其中（+）异构体的ED50计算为0.50毫克/千克，（-）异构体的ED50为1.07。时程数据表明，外消旋摇头丸在注射后20至60分钟达到峰值效应，在120至240分钟效应逐渐下降。这种时程与人类滥用者的主观报告所观察到的情况非常相似，并且与先前的数据一起表明，辨别范式在关于摇头丸神经化学效应的研究中将会很有用。
