Schechter M D
Pharmacol Biochem Behav. 1986 Jun;24(6):1533-7. doi: 10.1016/0091-3057(86)90480-6.
Groups of rats were trained to discriminate the stimulus properties of dopaminergically and/or serotonergically active drugs, viz., apomorphine, fenfluramine, tetrahydro-beta-carboline (THBC) and l-cathinone. Once trained, these animals were given several doses of drugs used in training and dose-response relationships and ED50 values were generated. Subsequently, each group of trained rats was administered various doses of 3,4-methylenedioxymethamphetamine (MDMA) to test generalization of the interoceptive cue of the drug used for training to MDMA. Rats trained to fenfluramine, THBC, and l-cathinone were observed to discriminate MDMA in a manner similar to the drug state to which they had been trained. Analysis of dose-response curves suggested that MDMA may be acting both as an indirect dopaminergic agonist and as a serotonergic receptor agonist. This duality of effect of MDMA has been evidenced by other studies and may account for its present abuse potential.
将大鼠分组训练，使其辨别多巴胺能和/或5-羟色胺能活性药物的刺激特性，即阿扑吗啡、芬氟拉明、四氢-β-咔啉（THBC）和L-去甲伪麻黄碱。一旦训练完成，给这些动物给予训练中使用的几种药物剂量，并得出剂量-反应关系和半数有效剂量（ED50）值。随后，给每组训练过的大鼠施用不同剂量的3,4-亚甲基二氧甲基苯丙胺（摇头丸），以测试用于训练的药物的内感受性线索对摇头丸的泛化情况。观察到经芬氟拉明、THBC和L-去甲伪麻黄碱训练的大鼠以类似于它们所训练的药物状态的方式辨别摇头丸。剂量-反应曲线分析表明，摇头丸可能既作为间接多巴胺能激动剂起作用，又作为5-羟色胺能受体激动剂起作用。摇头丸这种双重作用已被其他研究所证实，这可能解释了其目前的滥用潜力。
