a Department of Pediatrics, Baylor College of Medicine , Houston , TX , USA.
b Dan L. Duncan Cancer Center, Baylor College of Medicine , Houston , TX , USA.
Ethn Health. 2019 Oct;24(7):804-815. doi: 10.1080/13557858.2017.1373073. Epub 2017 Sep 4.
There are currently three licensed human papillomavirus (HPV) vaccines that protect against cervical cancer. Here we compare the prevalence of bi-, quadri-, and nonavalent vaccine-related HPV genotypes in a multi-ethnic sample of non-Hispanic white, non-Hispanic black, Hispanic, and Asian women. Patients in this analysis ( = 419) represent a subset of women with a previous abnormal Pap test participating in a clinical trial. HPV genotyping was conducted using the Roche Linear Array. Prevalent HPV genotypes were grouped according to their inclusion in each of the vaccines: bivalent (16, 18), quadrivalent (16, 18, 6, 11), and nonavalent (16, 18, 31, 33, 45, 52, 58, 6, 11). The prevalence of HPV genotypes covered by the bi-/quadrivalent vaccines was lowest among non-Hispanic black (15%) and Hispanic women (20%), compared to non-Hispanic white (38%) and Asian women (38%). Across all racial/ethnic groups, a large proportion of infections (38%-49%) were with genotypes included in the nonavalent vaccine. However, the prevalence of HPV genotypes not covered by any vaccine was significantly higher among non-Hispanic black (36%) and Hispanic women (42%), compared to non-Hispanic white (24%) and Asian women (16%) ( < 0.001). Racial/ethnic differences in HPV genotype prevalence were observed when controlling for demographic and sexual behavior characteristics, as well as when restricting the analysis to women with CIN 2+. Our data suggest racial/ethnic differences in the prevalence of vaccine-related HPV genotypes. In particular, non-Hispanic black and Hispanic women had the lowest prevalence of HPV genotypes covered by the bi-/quadrivalent vaccines. While a large proportion of their infections were covered by the nonavalent vaccine, non-Hispanic black and Hispanic women also had the highest prevalence of HPV genotypes not covered by any vaccine.
目前有三种获得许可的人乳头瘤病毒（HPV）疫苗可预防宫颈癌。在这里，我们比较了非裔美国人、非裔西班牙裔、西班牙裔和亚裔非西班牙裔白人女性多民族样本中双价、四价和九价疫苗相关 HPV 基因型的流行率。本分析中的患者（n=419）是参加临床试验的先前异常巴氏试验女性的一部分。HPV 基因分型使用罗氏线性阵列进行。根据它们在每种疫苗中的包含情况，将常见 HPV 基因型分组：二价（16、18）、四价（16、18、6、11）和九价（16、18、31、33、45、52、58、6、11）。二价/四价疫苗涵盖的 HPV 基因型在非裔美国人（15%）和西班牙裔女性（20%）中最低，而非裔西班牙裔白人（38%）和亚裔女性（38%）。在所有种族/族裔群体中，大多数感染（38%-49%）是九价疫苗涵盖的基因型。然而，在非裔美国人和西班牙裔女性（36%和 42%）中，未被任何疫苗涵盖的 HPV 基因型的流行率明显高于非裔西班牙裔白人（24%）和亚裔女性（16%）（<0.001）。在控制人口统计学和性行为特征以及将分析限制在 CIN2+女性时，观察到 HPV 基因型流行率的种族/族裔差异。我们的数据表明，疫苗相关 HPV 基因型的流行率存在种族/族裔差异。特别是，非裔美国人和西班牙裔女性中双价/四价疫苗涵盖的 HPV 基因型流行率最低。虽然她们的感染很大一部分被九价疫苗所涵盖，但非裔美国人和西班牙裔女性也有最高的未被任何疫苗涵盖的 HPV 基因型流行率。
