Department of Hypertension, Medical University of Lodz, Lodz, Poland.
Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
Atherosclerosis. 2017 Oct;265:275-282. doi: 10.1016/j.atherosclerosis.2017.08.027. Epub 2017 Aug 26.
The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylases with important roles in regulating energy metabolism and senescence. Activation of SIRTs appears to have beneficial effects on lipid metabolism and antioxidants, prompting investigation of the roles of these proteins in atherogenesis. Although clinical data are currently limited, the availability and safety of SIRT activators such as metformin and resveratrol provide an excellent opportunity to conduct research to better understand the role of SIRTs in human atherosclerosis. Encouraging observations from preclinical studies necessitate rigorous large, prospective, randomized clinical trials to determine the roles of SIRT activators on the progression of atherosclerosis and ultimately on cardiac outcomes, such as myocardial infarction and mortality.
沉默信息调节因子 2（SIRTs）是一类烟酰胺腺嘌呤二核苷酸（NAD）依赖性组蛋白去乙酰化酶，在调节能量代谢和衰老方面发挥着重要作用。SIRTs 的激活似乎对脂质代谢和抗氧化剂有有益的影响，促使人们研究这些蛋白质在动脉粥样硬化形成中的作用。尽管目前的临床数据有限，但二甲双胍和白藜芦醇等 SIRT 激活剂的可用性和安全性为开展研究提供了极好的机会，以更好地了解 SIRTs 在人类动脉粥样硬化中的作用。来自临床前研究的令人鼓舞的观察结果需要进行严格的大型前瞻性随机临床试验，以确定 SIRT 激活剂在动脉粥样硬化进展以及最终在心肌梗死和死亡率等心脏结局方面的作用。
