载没食子酸壳聚糖/聚乙烯醇水凝胶复合材料的研制：释放特性和抗氧化活性。
Development of a gallic acid-loaded chitosan and polyvinyl alcohol hydrogel composite: Release characteristics and antioxidant activity.
机构信息
Materials and Textile Technology, Faculty of Science and Technology, Thammasat University, Patumtani, Thailand.
Laboratory of Organic Synthesis, Chulabhorn Research Institute, Bangkok, Thailand.
出版信息
Int J Biol Macromol. 2018 Feb;107(Pt A):363-370. doi: 10.1016/j.ijbiomac.2017.09.002. Epub 2017 Sep 19.
The physico-chemical properties of a chitosan and polyvinyl alcohol (CS/PVA)-based hydrogel composite were investigated. Tetraethyl orthosilicate (TEOS) was employed as a crosslinking agent. The results indicated that the chitosan-based composite presented a thermal resistance up to 200°C. The structural properties, which were evaluated using FTIR and DSC, showed good miscibility between chitosan and polyvinyl alcohol. SEM presented a compact and homogeneous structure. The release profile of the chitosan-based hydrogel composite was investigated using gallic acid (GA). It showed high antioxidant activities, which were monitored using DPPH radical scavenging. Diffusion of water into the chitosan-based hydrogel was assumed to be pseudo-Fickian in PBS solution. The CS/PVA-based hydrogel composite exhibited good properties as a drug delivery system.
研究了壳聚糖和聚乙烯醇（CS/PVA）基水凝胶复合材料的物理化学性质。使用正硅酸乙酯（TEOS）作为交联剂。结果表明，基于壳聚糖的复合材料具有高达 200°C 的热稳定性。使用 FTIR 和 DSC 评估的结构性能表明壳聚糖和聚乙烯醇之间具有良好的混溶性。SEM 呈现出致密且均匀的结构。使用没食子酸（GA）研究了壳聚糖基水凝胶复合材料的释放曲线。它显示出高抗氧化活性，这是通过 DPPH 自由基清除来监测的。水在 PBS 溶液中扩散到壳聚糖基水凝胶中被认为是拟菲克扩散。CS/PVA 基水凝胶复合材料作为药物输送系统具有良好的性能。
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