Law Natalie, Ruane Laurence E, Low Kathy, Hamza Kais, Bardin Philip G
Monash Lung & Sleep, Monash Medical Centre and University, Australia.
Monash Lung & Sleep, Monash Medical Centre and University, Australia; Hudson Institute, Australia.
Respir Physiol Neurobiol. 2018 Jan;247:20-23. doi: 10.1016/j.resp.2017.08.011. Epub 2017 Sep 9.
Involuntary adaptations of breathing patterns to counter breathlessness may lead to dysfunctional breathing in obstructive lung diseases. However, no studies examining dysfunctional breathing in Chronic Obstructive Pulmonary Disease (COPD) have been reported. Patients with verified COPD (n=34), asthma (n=37) and a healthy control group (n=41) were recruited. All participants completed the Nijmegen questionnaire for dysfunctional breathing as well as measures of disease activity. Comparisons between groups employed analysis of variance with post-hoc Bonferroni analyses and Pearson correlation for associations. Patients with COPD had significantly higher Nijmegen questionnaire scores than asthmatics (COPD: 23.4±10.6 versus 17.3±10.6, p=0.016) and healthy individuals (14.3±9.6, p=0.002). Significantly more patients with COPD had severe dysfunctional breathing with Nijmegen scores >23 (47%; 16/34) compared to asthma (27%; 10/37) and healthy controls (17%; 7/41) respectively (p=0.019). Dysfunctional breathing was detected in ∼50% of patients with COPD, more so than in asthma or health. Strategies to reduce abnormal breathing behaviours may have important benefits for treatment of breathlessness in COPD.
呼吸模式的非自主适应以对抗呼吸急促可能会导致阻塞性肺疾病中的功能性呼吸障碍。然而，尚未有研究报道慢性阻塞性肺疾病（COPD）中的功能性呼吸障碍。招募了经证实患有COPD的患者（n = 34）、哮喘患者（n = 37）和一个健康对照组（n = 41）。所有参与者都完成了用于评估功能性呼吸障碍的奈梅亨问卷以及疾病活动度测量。组间比较采用方差分析，并进行事后邦费罗尼分析以及用于相关性分析的皮尔逊相关分析。COPD患者的奈梅亨问卷得分显著高于哮喘患者（COPD：23.4±10.6对17.3±10.6，p = 0.016）和健康个体（14.3±9.6，p = 0.002）。与哮喘患者（27%；10/37）和健康对照组（17%；7/41）相比，分别有显著更多的COPD患者存在严重的功能性呼吸障碍，奈梅亨得分>23（47%；16/34）（p = 0.019）。约50%的COPD患者存在功能性呼吸障碍，比哮喘患者或健康个体更为常见。减少异常呼吸行为的策略可能对COPD患者呼吸急促的治疗具有重要益处。
