Daskalakis Andreas, Patsaki Irini, Haniotou Aikaterini, Skordilis Emmanouil, Evangelodimou Afrodite, Grammatopoulou Eirini
Laboratory of Advanced Physiotherapy, Department of Physiotherapy, University of West Attica, 122 43 Egaleo, Greece.
Department of Respiratory Medicine, General Oncologic Hospital ''St. Anargyroi'', 145 64 Kifisia, Greece.
J Clin Med. 2025 Mar 29;14(7):2353. doi: 10.3390/jcm14072353.
The Nijmegen Questionnaire (NQ) has been a prevalent screening tool for dysfunctional breathing for the past 40 years. Until recently, the validity of the NQ has been established for the general population with hyperventilation syndrome (HVS) and for individuals with asthma, but not for people with COPD. The aim of the study was to examine the validity and reliability of the NQ in individuals with COPD. Construct, convergent, divergent and discriminant validity as well as internal consistency reliability were examined in a sample of 84 people with stable COPD. A three-factor solution with 16 items and 74.70% of explained variability was extracted through principal component analysis. High internal consistency (Cronbach alpha = 0.94) of the 16 NQ items was found. Significant differences were found between COPD individuals with and without DB ( < 0.001) and among people of all COPD levels of severity ( < 0.001). The value ">23" was found to detect the presence of DB, with 95.92% sensitivity and 94.29% specificity. Significant correlations were found between the total NQ score with BODE index ( = 0.81), Borg dyspnea scale ( = 0.47) and CAT ( = 0.49). The prevalence of DB for the specific sample was found to be 58.3%. The present study provided the first validity and reliability evidence for the NQ for people with stable COPD.
在过去40年里，奈梅亨问卷（NQ）一直是一种普遍使用的功能性呼吸障碍筛查工具。直到最近，NQ的有效性已在通气过度综合征（HVS）的普通人群和哮喘患者中得到证实，但在慢性阻塞性肺疾病（COPD）患者中尚未得到证实。本研究的目的是检验NQ在COPD患者中的有效性和可靠性。在84例稳定期COPD患者样本中，检验了结构效度、收敛效度、区分效度和判别效度以及内部一致性信度。通过主成分分析提取了一个包含16个项目、解释变异率为74.70%的三因素解决方案。发现16个NQ项目具有较高的内部一致性（Cronbachα=0.94）。在有和没有功能障碍性呼吸（DB）的COPD患者之间（<0.001）以及所有严重程度的COPD患者之间（<0.001）发现了显著差异。发现“>23”的值可检测到DB的存在，敏感性为95.92%，特异性为94.29%。发现NQ总分与BODE指数（=0.81）、博格呼吸困难量表（=0.47）和CAT（=0.49）之间存在显著相关性。发现该特定样本中DB的患病率为58.3%。本研究为稳定期COPD患者的NQ提供了首个有效性和可靠性证据。
