Allado Edem, Poussel Mathias, Hamroun Aghiles, Moussu Anthony, Kneizeh Ghias, Hily Oriane, Temperelli Margaux, Corradi Christophe, Koch Alexandre, Albuisson Eliane, Chenuel Bruno
CHRU-Nancy, Exploration Fonctionnelle Respiratoire-Centre Universitaire de Médecine du Sport et Activités Physiques Adaptées, F54000 Nancy, France.
DevAH, Université de Lorraine, F54000 Nancy, France.
Healthcare (Basel). 2022 Oct 28;10(11):2154. doi: 10.3390/healthcare10112154.
Following COVID-19 infection, many patients suffer from long-lasting symptoms that may greatly impair their quality of life. Persisting dyspnea and other functional respiratory complaints can evoke hyperventilation syndrome (HVS) as a putative contributor to long-COVID presentation in COVID-19 survivors. We aimed to assess the possible relationship between HVS and previous acute COVID-19 infection. We designed a cross-sectional, single-center study, including all patients consecutively referred to our Lung Function and Exercise Testing Department between January and June 2021. Participants completed a systematic Nijmegen Questionnaire, a modified Medical Research Council dyspnea scale assessment, a post-COVID screening questionnaire, and performed a standardized lung function test. The population was divided according to HVS diagnosis, defined as a Nijmegen score of > 23/64. The occurrence of previous COVID-19 infection was compared according to the Nijmegen score after adjustment for potential confounders by multivariate logistic regression. In total, 2846 patients were included: 1472 men (51.7%) with a mean age of 56 (±16.6) years. A total of 455 patients (16%) declared a previous SARS-CoV-2 infection, and 590 patients presented a positive score (>23/64) in the Nijmegen Questionnaire (20.7%). Compared with COVID-19-free patients, there was an increased occurrence of HVS+ in cases of COVID-19 infection that did not require hospitalization (aOR = 1.93 [1.17−3.18]). The results of this large-scale, cross-sectional study suggest an association between HVS diagnosis and a history of COVID-19 disease in patients who were not hospitalized.
感染新冠病毒后，许多患者会出现持续很长时间的症状，这些症状可能会严重影响他们的生活质量。持续的呼吸困难和其他功能性呼吸问题可能会引发过度通气综合征（HVS），这可能是新冠病毒感染者出现长期新冠症状的一个原因。我们旨在评估HVS与既往急性新冠病毒感染之间的可能关系。我们设计了一项横断面单中心研究，纳入了2021年1月至6月期间连续转诊至我们肺功能与运动测试科的所有患者。参与者完成了一份系统性的奈梅亨问卷、一份改良的医学研究委员会呼吸困难量表评估、一份新冠后筛查问卷，并进行了标准化肺功能测试。根据HVS诊断结果将研究对象分组，HVS诊断定义为奈梅亨评分>23/64。通过多因素逻辑回归对潜在混杂因素进行调整后，根据奈梅亨评分比较既往新冠病毒感染的发生率。总共纳入了2846例患者：1472例男性（51.7%），平均年龄56（±16.6）岁。共有455例患者（16%）宣称既往感染过严重急性呼吸综合征冠状病毒2（SARS-CoV-2），590例患者在奈梅亨问卷中的得分为阳性（>23/64）（20.7%）。与未感染新冠病毒的患者相比，未住院的新冠病毒感染患者中HVS阳性的发生率更高（调整后比值比[aOR]=1.93[1.17−3.18]）。这项大规模横断面研究的结果表明，在未住院的患者中，HVS诊断与新冠病史之间存在关联。
