Wen A, Weyant R J, McNeil D W, Crout R J, Neiswanger K, Marazita M L, Foxman B
Department of Biology, University of Northern Iowa, Cedar Falls, IA, USA.
Departments of Dental Public Health and Information Management, and Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA.
JDR Clin Trans Res. 2017 Jul;2(3):278-286. doi: 10.1177/2380084417698103. Epub 2017 Mar 15.
We conducted a Bayesian analysis of the association between family-level socioeconomic status and smoking and the prevalence of dental caries among siblings (children from infant to 14 y) among children living in rural and urban Northern Appalachia using data from the Center for Oral Health Research in Appalachia (COHRA). The observed proportion of siblings sharing caries was significantly different from predicted assuming siblings' caries status was independent. Using a Bayesian hierarchical model, we found the inclusion of a household factor significantly improved the goodness of fit. Other findings showed an inverse association between parental education and siblings' caries and a positive association between households with smokers and siblings' caries. Our study strengthens existing evidence suggesting that increased parental education and decreased parental cigarette smoking are associated with reduced childhood caries in the household. Our results also demonstrate the value of a Bayesian approach, which allows us to include household as a random effect, thereby providing more accurate estimates than obtained using generalized linear mixed models.
我们利用阿巴拉契亚口腔健康研究中心（COHRA）的数据，对居住在北阿巴拉契亚农村和城市地区的儿童（从婴儿到14岁）家庭层面的社会经济地位与吸烟及兄弟姐妹间龋齿患病率之间的关联进行了贝叶斯分析。观察到的兄弟姐妹间患龋情况的比例与假设兄弟姐妹的龋齿状况独立时的预测值有显著差异。使用贝叶斯分层模型，我们发现纳入家庭因素显著改善了拟合优度。其他研究结果显示，父母教育程度与兄弟姐妹的龋齿之间存在负相关，有吸烟者的家庭与兄弟姐妹的龋齿之间存在正相关。我们的研究强化了现有证据，表明父母教育程度的提高和父母吸烟率的降低与家庭中儿童龋齿的减少有关。我们的结果还证明了贝叶斯方法的价值，该方法使我们能够将家庭作为随机效应纳入，从而提供比使用广义线性混合模型更准确的估计。
