通过脱羧/羟醛反应实现的铜催化芳族醛的二氟烷基化反应。
Copper-catalysed difluoroalkylation of aromatic aldehydes via a decarboxylation/aldol reaction.
作者信息
Yuan Jin-Wei, Liu Shuai-Nan, Mai Wen-Peng
机构信息
School of Chemical Engineering And Environment, Henan University of Technology, Lianhua Street, Zhengzhou 450001, China.
出版信息
Org Biomol Chem. 2017 Sep 20;15(36):7654-7659. doi: 10.1039/c7ob01739a.
PMID:28871302
Abstract
A copper-catalysed tandem decarboxylation/aldol reaction of simple aromatic aldehydes with 2,2-difluoro-3-oxo-3-arylpropanoic acid has been developed under mild conditions. This method provides a new route for the direct one-pot synthesis of difluorinated aldols in moderate to good yields from simple substrates.
摘要
在温和条件下，已开发出一种简单芳香醛与2,2-二氟-3-氧代-3-芳基丙酸的铜催化串联脱羧/羟醛反应。该方法为从简单底物直接一锅法合成二氟代羟醛提供了一条新途径，产率适中至良好。
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